Mesenchymal stem/stromal cells (MSCs) are a promising therapeutic tool in cell therapy and tissue engineering because of their multi-lineage differentiation capacity, immunomodulatory effects, and tissue protective potential. To achieve optimal results a
Human iPSC-derived engineered heart tissue (hEHT) has been used to remuscularize injured hearts in a guinea pig infarction model. While beneficial effects on cardiac remodeling have been demonstrated, the arrhythmogenic potential of hEHTs is a major conc
From blood storms to honeycomb lungs, here’s an organ-by-organ look at how COVID-19 harms humans.
J. An acellular biologic scaffold does not regenerate appreciable de novo muscle tissue in rat models of volumetric muscle loss injury. Biomaterials 67, 393-407 (2015).Aurora A, Roe JL, Corona BT, Walters TJ (2015) An acellular biologic scaffold does not regenerate appreciable de novo muscle ...
The elderly and patients with several comorbidities experience more severe cases of coronavirus disease 2019 (COVID-19) than healthy patients without underlying medical conditions. However, it is unclear why these people are prone to developing alveolar
The liver is a unique organ with the ability to regenerate itself after acute damage as the differentiated hepatocytes re-enter in the cell cycle substituting the damaged hepatocytes [8]. In chronic liver damage, continuous activation of the immune cells in response to different stimuli triggers ...
does anyone know if nasal cilia can regenerate after quitting smoking. I've been smoking a pack to a pack and one half for twenty years. Byanon64287— On Feb 06, 2010 What substances paralyze the cilia? Byanon49810— On Oct 23, 2009 ...
in tissue surveillance and homeostasis, have evolved specialized functions dependent on the tissue of residence, such as recycling erythrocytes in the liver (Kupffer cells) or spleen (red pulp Mac), repurposing surfactant in the lung (alveolar Mac) and remodeling synapses (brain microglia) [112]....
By aiming to rescue damaged cells and regenerate damaged tissue or modulate inflammatory pathways extensive research has been conducted over the last decades mainly with mixed or negative results. Hurdles like the optimal application strategy, poor survival and engraftment of the cells as well as a ...