Ketamine has been shown to be safe and effective in treating depression, but its mechanisms of action are not fully understood (Kadriu et al., 2020). One of the advantages of ketamine over traditional antidepressants is its rapid antidepressant effects. However, because no well-established ...
Ketamine: Ketamine was originally approved by the FDA as an anesthetic in the early 1970s. More recently it’s been used to treat very severe depression, like the kind that manifests as thoughts of imminent suicide. This medication can only be used short-term, but might have lasting benefits...
injection of ketamine (100 mg/kg) and xylazine (10 mg/kg) dissolved in sterile saline solution. Mice were then placed in a small-animal stereotaxic device (Kopf Instruments) and the skull surface was exposed. 33-gauge needles (Hamilton) were utilized to infuse 1.0 μL of virus at...
was introduced to ketamine in 2017 at a festival in Los Angeles. One small bump tuned out their usual self-conscious worries, which felt revolutionary for someone who’d long struggled withbody dysmorphia, bulimia, and depression. “I love dancing, but there’...
Circadian-dependent changes in glymphatic influx under ketamine/xylazine anesthesia were not altered by sex. This was not true for diurnal rhythms under pentobarbital and avertin, but both still showed daily oscillations independent of biological sex. Finally, although glymphatic influx decreases with age...
some psychotropics that will undo the damage and create a lot of a neural reset for people who have had longstanding damage, much of the work i do is helping people get off their meds with ketamine. and so, if they're stuck on opiates, if they're stuck on high doses of antidepressan...
After 3 days, animals were euthanized with sodium pentobarbital, according to AVMA guidelines, and brains were collected for histological analysis of hippocampal neuronal cell death. The procedures were performed under anesthesia, induced with intramuscular administration of 10 to 20 mg/kg ketamine and...
Dr. Margaret Westwater, who led the research while a PhD student at Cambridge’s Department of Psychiatry, said: “The idea was to see what happened when these women were stressed. Did it affect key regions of the brain important for self-control, and did that in turn lead to incr...
degree in journalism from New York University's Science, Health and Environmental Reporting Program. She also holds a B.S. in molecular biology and an M.S. in biology from the University of California, San Diego. Her work has appeared in Scienceline, The Washington Post and Scientific ...
JS:There are some who might say this guy's depressed so the depression is at work here and somehow deny you the creator of the full credit you deserve for realizing these masterpieces. Would these works be different if you were in different mood states while you made them? Or is that ju...