PNPLA3 (adiponutrin, calcium-independent phospholipase A2 epsilon [iPLA2∊]) is an adipose-enriched, nutritionally regulated protein that belongs to the patatin-like phospholipase domain containing (PNPLA) family of lipid metabolizing proteins. Genetic variations in the human PNPLA3 gene (i....
As expected, there was a significant increase in body weight (BW) in vehicle- and dapagliflozin(DAPA)-treatedApoe−/−Irs2+/−mice after receiving the atherogenic diet (Figure 1a) both in females and males. No differences were observed in BW between DAPA- and vehicle-treated mice. Simil...