As a catabolic and glucoregulatory hormone, downstream cortisol is secreted in response to physical stress and other challenges to body homeostasis [91]. In turn, the hypothalamic–pituitary–thyroid axis controls metabolic hormones that play a key role in regulating musculoskeletal health and function...
Gluconeogenesis is one of the important cellular processes in the body. Here are some clinical conditions in relation to this process: Glucosuria In hyperglycemia, the glomerular filtrate may contain more glucose than can be reabsorbed and this occurs when the venous blood glucose concentration ...
Glucose was sampled by tail vein using an Accu-Chek Compact Plus Glucometer (Roche Diagnostics) at baseline, 15, 30, 60 and 120 min after administration. Spleen histology. After harvest and weighing, spleens were placed lengthwise in a cassette and fixed in 10% formalin for 48 h, then ...
Obesity and type 2 diabetes: slow down!—can metabolic deceleration protect the islet beta cell from excess nutrient-induced damage? Mol Cell Endocrinol 2010; 316: 140–146. Article CAS Google Scholar Prentki M, Nolan CJ . Islet beta cell failure in type 2 diabetes. J Clin Invest 2006; ...
The 4th International Conference on Controversies in Vitamin D was held as a virtual meeting in September, 2020, gathering together leading international s
Download keyboard_arrow_down Browse Figures Review Reports Versions Notes Abstract Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise ...
Downloadkeyboard_arrow_down Browse Figure Versions Notes Abstract Background: Bipolar disorder is a chronic psychiatric disorder with depression and manic episodes. It is one of the leading causes of disease-related disability worldwide. Despite the presence of various alternative drug options for bipola...
Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract It is well established that regular exercise plays an important role in achieving a number of health and wellbeing outcomes. However, certain post-exercise behaviors, including the consumption of unhealthy high-calorie foods, can countera...
(0.5 U/Kg of BW Humulina, Lilly, Alcobendas, Spain) were performed in overnight- and 4-h-fasted mice, respectively. Glucose levels were measured at different time points using a glucometer (Ascensia Elite, Bayer, Leverkusen, Germany). Fasting basal insulin and insulin-release and C-peptide...
According to the work of Rodriguez-Rodriguez et al., who showed that the toxicity of TAC depends on the pre-existence of β-cell dysfunction, we modeled glucolipotoxicity to the INS cells with glucose (22 mmol/L) and palmitate (100 μmol/L) for 5 days before we started the 12 h Tac...