The outcomes measured in this meta-analysis were gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), total cholesterol (TC), waist circumference (WC), and liver fibrosis. Ten randomized controlled trials, which involved a total of 737 adults with NAFLD, were included. A...
CA, USA) and are depicted as mean values with error bars indicating standard error of the mean (SEM). For each experiment, the number of animals (n) and the statistical test are indicated in the figure legend. Normal distribution within each group was verified using the D’Agostino and Pea...
Adenoviruses expressing two mouse PPARδ shRNAs with the sequences, GGAGCATCCTCACCGGCAA and GCAGCTGGTCACTGAGCAT, were generated by Welgen (Worcester, MA). In the PPARδ knockdown experiments, these two viruses were used at a 1:1 ratio. The adenoviruses expressing PGC-1β shRNA, PGC-1α...
All patients underwent upper endoscopy and were also subjected to liver and spleen elastography (using the new probe of 100 Hz) by the same blinded operator in a tertiary center. Results: We included 155 cirrhotic patients, with a mean age of 64.1 years (±8.8), and 81.3% were male. ...
Results: Adenine mice exhibited significantly higher mean serum urea, creatinine, and renal expression of the pro-inflammatory markers Interleukin-6 (IL-6), C-X-C motif chemokine 10 (CXCL10), and Interleukin-1β (IL-1β), in addition to prominent renal fibrosis and reduced renal Klotho gene...
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Cyclophilin showed constantly the highest homogeneous level of expression in all organs, with an average quantification cycle (Cq) of 21.5 [+ or -] 1.5, whereas [beta]-actin and GAPDH expression levels were lower and less constant in all tissues, with a Cq mean of 26.0 [+ or -] 2.2 and...
Aim: To investigate the association of elevated GGT activity with the 10-years risk of cardiovascular events in patients with liver steatosis. Methods: A total of 100 patients (mean age: 48,15 卤 10.5 years, 72% males) who had liver steatosis were included in the study. The 10-years ...
The mean ages and gender distributions of the two cohorts were similar. At presentation, PBC alone patients had greater disease activity (higher serum ALP and GGT values, P =.003 and 0.01, respectively) and advanced disease (higher Fib-4 ( P =.04) scores) than PBC/NAFLD patients. ...
(SSDD)) WWGGTTTT (hours), mmeeaann((SSDD)) 3P0l.a9c(e1b9o–(7n1,=1369.0) ) 30.9 3(169(–9721.,31)6.0) 2336.9(9(23.3.3)) 2135..93 ((32..34)) 152.38 ((23..43)) 152..48 ((33..03) 52..48 ((31..01)) 25151...85757 (((12020...14646))) 11..44 ((00.....