The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease 来自 NCBI 喜欢 0 阅读量: 30 作者:V Beaumont,L Park,A Rassoulpour,U Dijkman,Ignacio Munoz-Sanjuan 摘要: Huntington's disease is a neurodegenerative disorder caused by ...
To elucidate the role that HDAC6 plays in HD progression, we evaluated the effects of the genetic depletion of HDAC6 in the R6/2 mouse model of HD. Loss of HDAC6 resulted in a marked increase in tubulin acetylation throughout the brain. Despite this, there was no effect on the onset ...
P = 0.625). Furthermore, we showed that heterozygote deletion ofS6k1did not affect the reduced performance observed in the R6/2 mice as R6/2 × S6k1+/−mice showed a similar decline in overall performance as both the R6/2 and R6/2 × S6k1−/−mice (F2,18 =...
R1-R6 CrossrefView in ScopusGoogle Scholar 32 D.A. Polson, M.P. Thompson Macronutrient composition of the diet differentially affects leptin and adiponutrin mRNA expression in response to meal feeding J. Nutr. Biochem., 15 (2004), pp. 242-246 View PDFView articleView in ScopusGoogle ...
NOX inhibitors could be potential therapeutic agents to prevent disease progression in selected patient cohorts. Moreover, the novel concept could provide a molecular rationale to better explain recent advances in treating ALD, e.g. with intravenous infusions of antioxidants such as N-acetylcysteine [...
As the kidney plays a major role in the clear- ance of AGEs from the body, there has been much debate as to whether consumption of dietary AGEs can precipitate and/or contribute to progression of CKD and, hence, whether lowering dietary AGE intake or targeting this pathway might be of ...
Increased ROS synthesis leads to oxidative damage to proteins, lipids and DNA, which is a direct cause of the onset and progression of breast cancer and other malignancies. Indeed, disturbances of redox balance and severe oxidative damage have been observed in both serum/plasma as well as tumor...