These findings lay the groundwork for understanding the biological processes involved in complex real-life environmental challenges. Further studies are needed to expand upon and provide deeper insights into the specific mechanisms and identify biomarkers for risk and resilience, using deeply phenotyped da...
83whereas Akt2 has been identified as the main isoform for anxiety and depression behavior in mice.84It would be interesting to study whether there is divergent regulation of Akt isoforms by EC consumption in different brain areas. Indeed, the mechanism underlying Akt induction in cortex is unclea...
A recent review by Pignolo et. al. proposed two overarching criteria for attaining exceptional longevity: (1) biological age < chronological age, (2) slowed or delayed decline in functional status (López-Otín and Kroemer2021). Considering the work of Rowe and Kahn, the functional aspect ...
However, applying these criteria does not rule out the possibility that documents that meet the requirements for ineligibility may have been overlooked and continue to be included in the work plan. 2.4. Phase#4: Quality Criteria Systematic literature reviews (SLRs) typically employ several quality ...