We first explored if the different Y truncations can affect heterochromatin formation on other chromosomes, as predicted. We turned to a well-established paradigm: the graded effect of the Y chromosome on position-effect variegation (PEV)27. One of the best examples of PEV is seen when thewhit...
231 = 0.338, P = 0.858). Additionally, we showed that heterozygote deletion ofS6k1did not affect the reduced performance observed in the R6/2 mice as R6/2 × S6k1+/−mice showed a similar decline in performance over time as both the R6/2 and R6/2 × S6k1−/...