and, ultimately, the project cost. The method was validated as per the ICH guidelines. The linearity was in the range of 2–33.5 µg/mL with LOD and LOQ values of 0.85 and 2.58 µg/mL, respectively. The accuracy and precision results were well organised, and %RSD was within ± ...
Additionally, the results of an OVAT study are dependent on the starting settings of the optimization process and as such, OVAT is prone to finding only local optima and may thus miss the true set of optimal conditions23. An alternative to the OVAT approach is factorial experimental design or...
Thermal degradation study was carried out by heating a mixture of 1 mg/mL drug solution and 2 mL of Milli-Q water at 60 °C for 24 h. The resulting solution was diluted and analyzed using HPLC. Preparation of Mucoadhesive Beads The ionic gelation process was utilized to prepare the drug-...
The nuclear fuel facilities being built by both firms expect that DOE’s funded production of HALEU by the new centrifuges at CENTRUS will result in the required enrichment levels of U235 to meet their needs in the gaseous form of uranium hexafluoride (UF6). This material will go to a con...
the Pt nanoparticles are well separated and uniformly distributed on the surface of SWNT bundles, presumably as a result of platinum coordination by carboxylate groups, while in the case of the non-functionalized SWNT-NF material the Pt particles aggregate to form line-type fragments oriented along...
supernatantViralclearancestudy Processeconomy Summary Outline 2/ GE/ 2023/10/ 15 Fed-batchtiterof2,7g/Lreportedalreadyin1997(Zhouet al)usingGSgeneexpressionsystem ≥1to2g/Lconsideredtobecurrentindustrialstandard 10g/Lestimatedtobeachievedinnext5years ...
Through this, researchers could understand the relationship between atoms and their respective bond. The study is envisioned to help in storing energy more effectively while achieving stability. ION Energy The Mumbai-based startup, through its ML-based platform, is helping users to improve the perfor...
By assessing the bonding strength between the mucin and the used polymers in the tablets, the mucoadhesive qualities of the formulations were assessed. The study used the viscosimetric technique and modified the methodology described by Hassan and Gallo [19]. The viscosity of the formulations was ...
The censored raw data presented in the study are included in the supplementary material (Supplementary_SF_RawData). Conflicts of Interest M.K., A.W., B.P., M.B., M.A.H., J.M., T.W., P.B. and P.K.M. employed by Boehringer Ingelheim Pharma GmbH & Co. KG. The remaining au...
(CQAs) to critical material attributes (CMAs) and critical process parameters (CPPs), defining a process design space that originates a final product with the desired QTPP, developing a risk control strategy to identify the causes of variability, and continuous monitoring and improving the ...