Sleep medication affects sleep duration but there are also indications of adverse effects on cognitive function [50]. Another methodological issue is that participants in cohort studies usually have a relatively healthy profile and a certain drop-out of initial participants is inevitable. Despite the ...
The reason for this lack of efficacy is the inability of the medication to reach the site of action at required concentration levels. One of the new ways to improve medication concentration at the gastric mucosa is using gastro retentive drug delivery system (GRDDS), which increases the drug ...