For multi-slice spatial domain detection, firstly, SpaDo calculates SPACE of cells or spots for each slice. Because all slices have consistent cell type annotations, i.e., they have the same embedding space, we concatenate SPACE of each slice together to calculate the JSD distance and then pe...
If the cross-linking between DNA and protein is not repaired in time it is very harmful and deadly to the plant (Popracet al. 2017). ROS détoxifications are carried out when plant cells, enzymes and redox metabolites function synergistically to protect themselves from adverse effects. ...
in voluntary DNA testing, new links in family trees are discovered. Services such as23andMe,AncestryDNA, and others offer DNA testing for a fee. But there are questions about the reliability of the results, and privacy concerns too. See my articleIs Someone Searching for Your DNA Online?
An alternative approach involves transforming cells derived from suspension cultures of citrus embryogenic calli (Omar et al.2016,2018; Dutt et al.2020). The use of cationic lipid-based carriers, such as Lipofectamine, provides a viable method for delivering donor DNA and achieving successful genome...
Tuesday, November 26, 2024 AI is revolutionizing drug discovery by providing rapid access to vast and complex datasets, enabling researchers to quickly uncover valuable insights and connections that would be otherwise difficult to observe. By automating routine tasks, enabling advanced analytics, and str...
After you have finished mixing all of the reagents in your reaction tube, how and why should you store your samples? Why do cancer cells divide? Why do eudicot trees tend to be wider at the base than at the top? Why is p53 a tumor suppressor and why does MDM2 bind to it?
Using a set of 40 reporter gene assays in mammalian cells, activity profiles of small molecules have been generated and compared. King et al. showed that the known dihydroorotate dehydrogenase inhibitor brequinar clusters with the natural product terprenin and could confirm that terprenin indeed ...
(red cell in between orange cells). (2) The newly nuclear mitogene (nu) is beneficial and sweeps to fixation in a population due to natural selection, while the mitochondrial mitogene (mito) is lost because of bioenergetic benefit. New adaptations (nu*) will evolve in response to the new...
The urgent need for new antimicrobials arises from antimicrobial resistance. Actinobacteria, especially Streptomyces genus, are responsible for production
During the recovery interval, the RNA polymerase is stalled to be activated by a pause-breaking factor in the subsequent drought. Drought leads to DNA demethylation near drought-response genes, with genetic control of the process. Progenies of the drought-exposed plants can better adapt to drought...