p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, ...
Antibodiesare proteins that some of our immune cells create to help fight off infections. These antibodies are unique to the germs that can cause an infection. Our bodies develophigherantibody levels after being sick or getting a vaccine. Here, we’ll explain how our immune system makes antibodi...
large biomolecules such as antibodies, and even other cells—that cannot freely cross the plasma membrane. Endocytosis is essential for normal cell functioning, and many viruses and bacteria have evolved mechanisms to hijack endocytic ...
What is the complement system? Learn about complement proteins of the body, functions of the complement system, and understand the complement activation processes. Related to this QuestionDoes the complement system produce antibodies? Does the complement system have to be antibody directed? Do antibodie...
Describe how lipids and proteins are distributed in the plasma membrane and explain the functions of each. (a) What is the use of protein in the body? (b) Where could be found most of the protein in the human body? What are the antibodies main purpose and how do they function? What ...
The maleimide reacts with free sulphydryl groups produced by the reduction of cysteines in proteins or peptides. Maleimides are particularly useful for labeling antibodies as the dye will not attach to the antibody binding site. This reaction will result in a stable conjugate that can be used...
It is mediated by antibodies or lymphocytes or both which make the antigen harmless. It not only relieves the victim of the disease but also prevents its further attack in the future. The memory cells formed by B-cells and T-cells are the basis of acquired immunity. Thus, this immunity co...
Biologicals roughly consist of three main groups: 1) antibodies, 2) fusion proteins, and 3) cytokines. Because biologicals target molecules with high specificity, they selectively interfere with immunological or biological processes. Consequently, biologicals can be used for intervention in a variety of...
(HIER), which uses heat to break apart cross-linked bonds and unwind proteins. Either method can unmask epitopes, rendering them accessible to the primary antibody and amenable to staining by IHC. At CST, we most often use HIER when testing our antibodies, so this is the method we wil...
Antibodies are essentially proteins that are capable of binding to specific regions of an antigen known as epitopes. These regions are naturally...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough homework...