The D-Ala-D-Ala building block as well as the structure of the bacterial cell wall is considered to be unique to prokaryotes. Consequently, PBPs and class A, C, and D ß-lactamases being acyl serine transferases are considered to be bacteria specific [156]. But structural homologies ...
Prokaryotes and eukaryotes (80S) have a different structure to ribosomes so can use antibiotics for selective toxicity against ribosomes of prokaryotes (70S) Mechanism of Action INHIBITION OF PROTEIN SYNTHESIS (cont’d) Aminoglycosides bind to bacterial ribosome on 30S subunit; and blocks formation o...
and prokaryotes S-D sequence 5' methylG cap and 3' poly-A tail 2.2 Translation in eukaryotes Eukaryotic mRNAs have a distinct structure at the 5’ end Ribosome structure in prokaryotes & eukaryotes 70S = 2.8 million daltons Process of translation in eukaryotes Initation Elongation ...
5]. The D-Ala-D-Ala building block as well as the structure of the bacterial cell wall is considered to be unique to prokaryotes. Consequently, PBPs and class A, C, and D ß-lactamases being