Mucopolysaccharidosis type II (MPS II) is a rare X-linked recessive inherited lysosomal storage disease. With pathogenic variants of the IDS gene, the activity of iduronate-2-sulfatase (IDS) is reduced or lost, causing the inability to degrade glycosamin
Since DOK6 acts as an adapter protein-mediated tyrosine kinase signal, to gain insight into howDok6deletion leads to PNS axon degeneration, we performed a DOK6-GST pull-down assay with lysates from E18.5 brain tissue (due to the limited amount of protein in the sciatic nerve) to identify ...
One the ribosomes have synthesized a protein, they are “labeled” with a specific final destination. Some proteins are sent to theGolgi apparatus, while others are secreted into the cell exterior or kept within the membrane of the rough endoplasmic reticulum itself. There are certain proteins th...
or protein synthesis, on the ribosome. After a protein is fully synthesized and released by the ribosome into rough ER, a number of things may happen. The protein may be "tagged" with a chemical "label" on the inner membrane of the ER...
Cells are the basic building blocks of life. Less poetically, they are the smallest units of living things that retain all of the basic properties associated with life itself (e.g., protein synthesis, fuel consumption and genetic material). As a result, despite their tiny size, cells have ...
Peroxisomes were indeed shown to interact with ER, lysosomes, mitochondria, and lipid droplets and participate in cholesterol trafficking [137, 138]. ABC transporter-dependent lipid rearrangement and immunity It remains to be established whether ABC transporters are master planners of dynamic membrane ...
SARS-CoV-2, similarly to SARS-CoV, is known to invade the host cells by the viral spike protein that mediates fusion of the viral envelope with the cell membrane, or by exiting the endosome or lysosome also via membrane fusion (Fig.1B). Angiotensin-converting enzyme 2 (ACE2), which is...
It is pos- sible that ESCRT complexes are recruited into the viral replicase complex at some stages to help the virus to evade the recognition by host defense proteins and/or to avoid the degradation by the gene silencing machinery. Indeed, the p33 replication protein...
(E. coliand latex beads), confirming the presence of phagocytes in this tissue. Furthermore, two of the top-expressed transcripts in the nematosomes share homology with uromodulin (Nv46 and Nv111), a glycoprotein known to be involved in protein-protein interactions associated with the ...
with SARS- CoV, such as glucose-regulated protein 78 (GRP78 or BiP) and glucose-regulated protein 94 (GRP94) [59]. ER stress can also be activated by pro-inflammatory cytokines [60]. Several SARS-CoV proteins have been shown to induce the ER stress response such as the Spike protein ...