In adult patients with severe renal impairment (creatinine clearance less than 30 mL/minute), the systemic exposure (AUC) of famotidine increased at least 5-fold. In patients with moderate renal impairment (creatinine clearance between 30 to 60 mL/minute), the AUC of famotidine increased at leas...
in sinus rhythm at six months and the change in QTc from baseline at steady state of dosing increased in an approximately linear fashion with increasing dose of TIKOSYN. Note that in these studies, doses were modified by results of creatinine clearance measurement and in-hospital QTc prolongation...
(n=8). The mean half-life of midazolam increased 2.5-fold in the patients with cirrhosis. Clearance was reduced by 50% and the Vd increased by 20%. In another study in male patients with cirrhosis (n=21) without ascites and with normal kidney function as determined by creatinine clearance...
Physical performance, fasting plasma glucose levels, oral glucose tolerance, serum creatinine levels, and A1C levels were also tested regularly throughout the study. Results: Multivariate analysis included the additional variables of change in body weight, change in diastolic blood pressure, and the ...
No clinically relevant changes were noted in serum potassium, serum glucose, total TG, TC, HDL-C, uric acid, blood urea nitrogen, or creatinine. Atorvastatin In the atorvastatin placebo-controlled clinical trial database of 16066 patients (8755 atorvastatin vs. 7311 placebo; age range 10‑93...
There was no change in urine GAG during the study. Subject #1 urine GAG at baseline was 6.3 mg/mmol creatinine, 5.7 mg/mmol creatinine after 16 weeks treatment, and then 6.2 mg/mmol creatinine after 16 weeks placebo (normal for age < 6.5 mg/mmol creatinine). Subject #2 urine GAG at ...
Urine (0.207 μmol creatinine equivalents) was mixed with 2.608 nmol of a disaccharide (Man(β1-4)GlcNAc) which served as an internal standard and freeze-dried. Glycans were derivatized with the 2-aminobenzamide as previously described, with minor modifications[17]. The freeze-dried glycans were...
White blood cell count was significantly higher among COPD subjects, while CHF subjects demonstrated signifi- cantly higher levels of creatinine. The level of B-type natriuretic protein (proBNP), a marker of CHF, was generally elevated among CHF subjects, while the level of the stable metabolite...
participants who showed mental disorders, a history of previous cardiovascular disease or diabetic foot disease, chronic kidney disease (defined as an estimated glomerular filtration rate < 60 mL/min or a urine albumin/creatinine ratio over 300 mcg/g), pregnancy, and other conditions that could inf...
The clinical phenotype of sepsis-induced acute kidney injury is character- ized by profound decreases in GFR and creatinine clearance and development of uremia[59]. The sepsis-induced decrease in GFR is expected to lead to the decreased renal excretion of 5, and in turn, an increased level of...