DNT (Double-Negative T) cells are a subpopulation of CD3 positive and CD4/CD8 negative T-cells normally present in human peripheral blood, accounting for 1-10% of all T cells. DNT cells express CD3 molecules and αβ- or γδ- T cell receptors (TCR) on their surfaces, but not CD4 or...
针对临床allo-HSCT后复发的AML患者,目前国内外治疗手段极其有限,是困扰临床治疗的一大难题。 早在2000年,多伦多大学张丽教授团队在 Nature Medicine 发表论文,发现了一种特殊的 T 细胞亚群——双阴性 T 细胞(double-negative T cells,DNT),它们不表达 CD4 和 CD8,并因此得名。后续研究中,张丽团队发现,从AML患者或...
针对临床allo-HSCT后复发的AML患者,目前国内外治疗手段极其有限,是困扰临床治疗的一大难题。 早在2000年,多伦多大学张丽教授团队在 Nature Medicine 发表论文,发现了一种特殊的 T 细胞亚群——双阴性 T 细胞(double-negative T cells,DNT),它们不表达 CD4 和 CD8,并因此得名。 后续研究中,张丽团队发现,从AML患者...
双阴性T细胞(即DNT细胞,Double Negative T cells)是该项目负责人杨黎明博士等人在加拿大多伦多大学医学院教授张丽实验室发现的,是人体自身具有的。临床前研究结果证明,健康人或患者外周血体外扩增,获得的DNT细胞能在小鼠体内外杀死包括对化疗耐受、难治性病人的急性粒细胞白血病干细胞等。尤其重要的是,DNT细胞在有效杀死...
The DNT cells discovered in recent years, namely TCR + , CD3 + , CD4 -, and CD8 - T cells, are T-cell subpopulations with unique immunomodulatory functions, and their expression of Fas/FasL, TNF/TNFR, and MHCI, etc. They have an important role in anti-tumor, immune regulation, ...
际 InternationalJournalofSurgery March2009,Vo1.36,No.3 · 155 · 【关键词】 DNT细胞;免疫磁性分离;外周血 DNT cellsisolatedandidentifiedin theperipheralbloodanditscontentde- tection CHENJiong,DUMin,YANGBing,TANGHou—Kuo,ZHAIz —Min,LIQ DepartmentofGeneralSurgery,AffiliatedtoProvicial HospitalofAnhui...
[2] Daniel Vasic et al., Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities. SCIENCE IMMUNOLOGY, 22 Apr 2022, Vol 7, Issue 70. DOI: 10.1126/sciimmunol.abl3642. [3] Yang LM...
This ar ticle mainly introduces the advancement of one subet ofDNT cell, DN Tregs, in tumor.[Key words] DNT cells; tumor CD4CD8双阴性T细胞(CD4CD8 double-negativeT cel ls, DNT cells)是指一类细胞表面既不表达 CD4分子同时也不表达 CD8分子的 T细胞群,而根据CD4CD8双阴性T细胞表面是否表达NK细胞...
(P<0.05),CD3+CD4-CD8+细胞比例升高(P<0.05).结论外周血DNT细胞比例的升高与乙型肝炎病毒感染者慢性化及慢性乙型肝炎患者的疾病进程有关.%Objective To investigate the changes of peripheral blood CD3 +CD4 -CD8 -T cells (double negative T,DNT) and T lymphocyte subsets in patients with hepatitis B ...
and define it as DNT cells in flow cytometry. We use MTT to prove DNT cells can inhibit the Panc-1 cells in vitro, and Nude mice experiment to prove DNT cells can inhibit the Panc-1 cells in vivo. We also use PCR to find out the mechanism of the ...