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Only the promoter region of the constitutively expressed normal and amplified human dihydrofolate reductase gene is DNase I hypersensitive and undermethylated. J Biol Chem. 1985 Feb 25; 260 (4):2468–2474. [ PubMed ]Shimada, T., and A. W. Nienhuis. 1985. Only the promoter region of the ...