In DNA templated synthesis (DTS) the effective local concentration of two or more reactants tethered to oligonucleotide strands is regulated by direct hybridization of the strands or by hybridization to a common template, bringing the reactants in close proximity. This provides efficient DNA-programm...
Some DNA-dependent RNA polymerases (DdRPs) possess RNA-dependent RNA polymerase activity, as was first discovered in the replication of Potato spindle tube... Wang,Y,Qu,... - 《Plant Cell》 被引量: 17发表: 2016年 The Functions of Histone Modification Enzymes in Cancer Posttranslational modifi...
RNA can act as a template for DNA synthesis in the reverse transcription of retroviruses and retrotransposons1and in the elongation of telomeres2. Despite its abundance in the nucleus, there has been no evidence for a direct role of RNA as a template in the repair of any chromosomal DNA lesi...
关键词: Saccharomyces cerevisiae Oligonucleotides DNA RNA DNA-Directed DNA Polymerase Templates, Genetic DNA Replication DNA Breaks, Double-Stranded DNA Repair DOI: 10.1038/nature05720 被引量: 173 年份: 2007 收藏 引用 批量引用 报错 分享 全部来源 免费下载 全文购买 Nature Nature (全网免费下载) ...
Recent developments have expanded the scope and capabilities of DTS from its origins as a model of prebiotic nucleic acid replication to its current ability to translate DNA sequences into complex small-molecule and polymer products of multistep organic synthesis. An understanding of fundamental ...
We would like to mention here that replication stress due to TLS deficiency under Pol η–deficient conditions leads to activation of ataxia telangiectasia and Rad3-related (ATR) kinase (57, 58). Thus, γH2AX, pATM, and p53BP1-mediated DNA damage response as observed here is due to Pol ...
The +RNA virus replication and transcription complex: hijacking membranes to accommodate viral RNA synthesis in the cytoplasm Viruses rely on the host cell?s infrastructure and metabolism during essentially all stages of their replication cycle and therefore have to coordinate a variety of molecular inte...
Thus, Rev1-dependent translesion bypass and mutagenesis is likely to be a trade-off for the ability to complete replication of a damaged template and thereby maintain genome integrity.J.E.e-mail:Salee-mail:L.J.e-mail:Simpsone-mail:
A head-to-head comparison of our modular, synthetic AcMNPV genome with native baculovirus vectors showed no significant difference in baculovirus growth kinetics or recombinant adeno-associated virus production鈥攕uggesting that neither baculovirus replication nor very-late gene expression were com...