wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, whereinthe antigenic peptide of (I) and the expres...
DNA spacing within hexagonal bundles of DNA and polycationic peptides correlates with interferon production in dendritic cells.doi:10.1038/nmat4332William M. GelbartDepartment of Chemistry and BiochemistryNature MaterialsW.M. Gelbart, DNA-peptode complexes: Regulation of interferon production, DNA ...
新技术合成Peptide-DNA材料 闲白:单纯的多肽研究,单纯的DNA或RNA相关结构的研究,已经满足不了广大科研工作者的需求,前段时间一位在读博士提到过 多肽和DNA连接,小编也找不到其它素材可以写了,于是今天就这个Peptide-DNA的合成,总结一下这方面的知识。 先来一张合成步骤图。 一、所需材料 1)amine-modified DNA: ...
Peptide-DNA conjugates are molecular chimeras composed of nucleic acid moieties covalently attached to polypeptide parts and are used in a variety of applications such as therapy and nanotechnology. A common strategy is to combine a cell-penetrating carrier peptide with a phosphorosulfate DNA chain th...
A short peptide corresponding to the nuclear localization signal (NLS) of human immunodeficiency virus (HIV)-1 Tat protein, Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg, was employed to improve the efficiency of cellular uptake of nucleic acids. The peptide was first mixed with a reporter plasmid and...
We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanot...
5-formylcytosine DNA–peptide cross-link translesion synthesis Introduction DNA is continuously exposed to a wide range of exogenous and endogenous DNA-damaging agents (1., 2.3). DNA–protein cross-links (DPCs)2 are formed when proteins become covalently bound to DNA (4, 5). Although DPC forma...
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As a tool for the optimization of sample preparation, ionization, fragmentation, and detection by mass spectrometry, novel synthetic DNA-peptide heteroconjugates were generated to act as mimics of UV cross-linked heteroconjugates. Click chemistry was employed to cross-link peptides to DNA ...
DNMT3A Antibody Blocking Peptide DNA甲基转移酶-3α封闭多肽 英文名称 DNMT3A Antibody Blocking Peptide 中文名称 DNA甲基转移酶-3α封闭多肽 别名 DNA (cytosine 5 ) methyltransferase 3 alpha; DNA (cytosine 5) methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA me...