Doxorubicin, one of the most common and potent chemotherapy drugs, works by linking random segments of DNA to one another to tangle them. This is like dripping superglue on a ball of yarn; it binds the DNA into a useless. The initial side effects of soxorubicin, in the few days after ...
6a–c). Therefore, to understand in more detail how it binds to DNA, a structural model of the CDF2DOF domain was made based on the crystal structure of a zinc-finger (Zif268)–DNA complex37 (Methods and Fig. 4d). Similar to what is generally found in classical zinc-finger (ZF) ...
1. Messenger RNA binds to the smaller of two subunits of large particles termedribosomes. 2. The amino acid that begins the assembly of the protein chain is activated and transferred to a specific transfer RNA (tRNA). The activation step, catalyzed by an aminoacyl–tRNA synthetase specific for...
ORF2p is actually one of the two proteins that the LINE-1 RNA tells the cell to make. Once ORF2p binds to the RNA’s tail, it sets in motion the steps needed for a jump to occur. Moran compares it to a Lego set—where one kind of tail could get unplugged and another slotted i...
The mammalian epigenome contains thousands of heterochromatin nanodomains (HNDs) marked by di- and trimethylation of histone H3 at lysine 9 (H3K9me2/3), which have a typical size of 3–10 nucleosomes. However, what governs HND location and extension is o
elements of all these viruses can be found in phycodnaviruses. Overall, the phycodnaviruses, like phage, also appear to be creating genes in large numbers and they encode many genes unrelated to their host. What then is the evolutionary relationship that links all of these seemingly distinct ...
Nobody has ever lost all their DNA,2 so we can't say for sure what the precise sequence of medical consequences would be. But to get an idea of what it might be like, let's turn to mushroom poisonings. 从来没有人失去过体内所有的DNA,2所以我们在这里并不能准确地知道之后会发生什么。但...
When a small circle binds a single strand by duplex formation, the strand must pass through the circle (forming a pseudorotaxane) if the binding interaction is ∼10 bases or longer.71 However, when triplex formation occurs, no topological link arises no matter how long the binding interaction...
what happens is, you heat this whole thing up to about boiling. You cool it down to room temperature, and as you do, those short strands do the following thing: each one of them binds that long strand in one place, and then has a second half that bi...
binds to the DNA and pre-designed sequence which contains Cas9. The RNA sequence is designed to find and locate specific sequence in the DNA. The Cas9 trails the guide RNA to the same location in the DNA sequence and makes a cut across both strands of DNA. At this point the cell ...