How can the structure and function of nucleotides (DNA and RNA) allow the cell to assemble specific proteins with different structures and functions? How does the double-helical structure of DNA relate to its function? Explain how the structure of DNA is well-suited for replication and its func...
Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity, but recent evidence suggests their involvement in key genome functions such as transcription, replication, genome stability, and ...
and Crick's discovery was also made possible by recent advances in model building, or the assembly of possible three-dimensional structures based upon known molecular distances and bond angles, a technique advanced by American biochemist Linus Pauling. In fact, Watson and Crick were worried that ...
2 Thierry AR, El Messaoudi S, Gahan PB,et al. Origins, structures, and functions of circulating DNA in oncology. Cancer Metastasis Rev, 2016, 35(3): 347-376. 3 Stroun M, Lyautey J, Lederrey C,et al.About the...
Growing evidence is implicating non‑B-form DNA structures in processes related to DNA stability and function, including replication and transcription. In particular, genomic studies are suggesting that sequences that could form G-quadruplex structures
Structure and function of nucleases in DNA repair: shape, grip and blade of the DNA scissors - Nishino, Morikawa - 2002 () Citation Context ... This task is accomplished by structure-specific endonucleases specialized in pruning downstream of branch, flap or bubble structures by incision at junc...
Such natural structures offer inspiration and blueprints for constructing DNA-assembled artificial systems, which mimic their functionality. In this talk, I will discuss DNA nanostructures with distinct motion and functions that interrogate...
ATR得名于“ataxia telangiectasia(共济失调毛细血管扩张症)and Rad3-related”,是激酶本身,而ATRIP则是ATR的伴侣蛋白。 ATR的激活,恰恰需要它与RPA结合,而RPA就是单链结合蛋白RPA(复制蛋白A, replication protein A)。 如果发生双链交联(ICL)损伤,那么基于与端粒缩短相同的原理(DNA只能5'→3'合成,且延伸需要引物...
How are the structures of RNA and DNA similar? How does DNA replication work? How does DNA have directionality? Identify and explain the functions of DNA. Support your answer by making references where appropriate. What role does DNA play in protein synthesis?
As discussed in Section “Discrete Self-Assembly of Homologous and Heterologous Metal Ions”, metallo-DNA structures have great potential as templates for predesigned self-assembly of metal complexes with a subnanometer resolution, which would provide characteristic physical properties corresponding to the ...