Each of these V domains has three hypervariable regions or CDRs. Two of the CDRs are encoded in the V gene. The third CDR is encoded by DNA that spans the splice junction between the V and J segments. Sloppiness
RepeatDNA sequencescan act as more or less discrete elements in the genome. They can vary in number of copies of repeat units from one chromosome to the next (polymorphism). The repeat copy number can expand through a unique form of mutation process that has been referred to as ‘dynamic ...
In the case of GacA, phosphorylation by the sensor kinase GacS promotes binding of GacA to the promoter regions of two small RNA genes, rsmY and rsmZ19. GacS is itself regulated by a second sensor kinase, RetS, which strongly inhibits GacS phosphotransfer to GacA20. To further evaluate ...
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs syndrome (RJALS) and AMeD syndrome (AMeDS) in
Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD), but the regulatory mechanisms underlying sex disparity in AD are still not well understood. DNA methylation is an important epigeneti
However, Horizontal Transfer (HT), the exchange of genetic information by other means than parents to offspring, was discovered in prokaryotes along with strong evidence showing that it is a very important process by which prokaryotes acquire new genes. Main body For some time now, it has been...
Humanized Mouse DNAm data of three tissues: blood, prefrontal cortex, and hippocampus, was available for two humanized mouse lines (carrying different alleles of the rs1360780 SNP) for the FKBP5 gene. Mice were treated with 2 mg/kg body weight dexamethasone or vehicle and tissue harvested ...
000 tumours and 28 types of cancer. The results show striking differences in the cancer-causing mutations found in people who are biologically male versus those who are biologically female — not only in the number of mutations lurking in their tumours, but also in the kinds of mutations found...
either as multiple observations in one or more forensic population sequence study(ies) (as submitted to STRSeq [13] through 2021) or one observation in a forensic population sequence study (in STRSeq through 2021) along with a confirming rs-number record in dbSNP build 155 [32] and/or obse...
The current number of different DNA sequences represented in the PDI-arrays depends on three main factors: the design of dsDNAs; the length of the oligonucleotide spotted onto the array; and the resolution of the array (i.e., number of different spots). Accordingly, optimum design choice is...