Their research paper; published today in the journalScience, reports that such communication between nucleotide supply and DNA replication speed is possible thanks to the fact that all sites in human genome that actively copy DNA contain a protein called PRDX2 that senses this chemical alert. When...
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, a... W Zhong,F Hui,FE Santiago,... - 《Nature》 被...
Chromosome replication is performed by a complex and intricate ensemble of proteins termed the replisome, where the DNA polymerases Polδ and Polε, DNA polymerase α-primase (Polα) and accessory proteins including AND-1, CLASPIN and TIMELESS–TIPIN (respectively known as Ctf4, Mrc1 and Tof1–...
We show that totipotent cells of the early mouse embryo have slow DNA replication fork speed and that 2CLCs recapitulate this feature, suggesting that fork speed underlies the transition to a totipotent-like state. 2CLCs emerge concomitant with DNA replication and display changes in replication ...
In Escherichia coli, adenine methylation at the sequence GATC allows coupling of cellular processes to chromosome replication and the cell cycle. The trans... Irina,Stancheva,Theodor,... - 《Embo Journal》 被引量: 227发表: 1999年 The Crystal Structure of the Bifunctional Primase-Helicase of Bact...
Focus on Relevant Research Just likeprokaryotes, eukaryotes have a specific order of proteins that load onto the origin of replication to control replication initiation. The eukaryotes have large numbers of proteins that are coordinately regulated to drive the cell through synthesis and then the complet...
Julian BlowLister Institute Research Fellow at the ICRF Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Herts. EN6 3LD, UK;Wiley Subscription Services, Inc., A Wiley CompanyBioEssaysBlow, J. 1992. A protein complex present at origins of DNA replication in yeast cells. Bio...
DNA damage encountered during the cellular process of chromosomal replication can disrupt the replication machinery and result in mutagenesis or lethality. The RecA protein of Escherichia coli is essential for survival in this situation: It maintains the integrity of the arrested replication fork and sig...
Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.关键词: Animals Humans Neoplasms Proto-Oncogene Proteins c-myc Transcription Factors RNA, Messenger RNA Caps DNA Replication ...
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of replication timing, we exploited inter-individual variation in hu