One such structure, with a "cloverleaf," is favored by ori nucleotide sequence comparisons and leads to potential novel macromolecular interactions.doi:10.1073/pnas.77.5.2460Noboru SueokaJun-ichi Tomizawamechanistic studies of dna replication & genetic recombination...
Summary DNA replication has an important role in the regulation of eukaryotic gene expression. The replication process transiently disrupts both active and repressed chromatin structures. This provides a key opportunity for mediating changes in the programming of genes. In those cases that have been tes...
Finally, we sought to address the functional relevance of the replication dynamics and fork remodeling for reprogramming to totipotency. Terminally differentiated somatic cells can be reprogrammed to totipotency upon transplantation into enucleated oocytes51,52. However, this process is inefficient and ofte...
Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses...
DNA replication occurs in a 5'→3' direction. 7.2.2 Explain the process of DNA replication in prokaryotes, including the role of enzymes (helicase, DNA polymerase, RNA primase and DNA ligase), Okazaki fragments and deoxynucleoside triphosphates. ...
DNA replication forks are tightly controlled by a large protein network consisting of well-known core regulators and many accessory factors which remain functionally undefined. In this study, we report previously unknown nuclear functions of the actin-bi
与DNA的解旋以及聚合酶的募集相偶联而真核细胞中这两个事件的短暂分离保证了在每个细胞周期中每条染色体仅仅只复制一次Initiation in eukaryotes requires two distinct steps:1st step---Replicator selection: the process of identifying sequences for replication initiation (G1 phase), which is mediated by the ...
Name: cassandra-0 Namespace: maglev-system Node: xxxx Start Time: xxxx Labels: addon=true adjustReplicationDuringNodeScale=async controller-revision-hash=cassandra-7f86d68787 nodeScale=3 serviceName=cassandra statefulset.kubernetes.io/pod-name=cassand...
Eukaryotic DNA replication refers to the process by which eukaryotic cells duplicate their DNA, involving the binding of the origin recognition complex (ORC) to replication origins, the formation of pre-replicative complexes (pre-RCs), and the initiation of DNA replication by helicase activity. This...
Fig. 1: Unscheduled replication in G1 initiates at canonical replication origins genome-wide. aSummary of engineered genetic changes that allow to bypass cell cycle control of DNA replication initiation and induce unscheduled replication in G1. Indicated proteins and variants are expressed from a gala...