"DNA replication in eukaryotic cells." Annu Rev Biochem 71: 333-74.Stephen P. Bell,Anindya Dutta.DNA REPLICATION IN EUKARYOTIC CELLS[J]. Annual Review of Biochemistry .2002Bell SP and Dutta A (2002) DNA replication in eukaryotic cells. Annual Review of Biochemistry 71: 333-374....
The maintenance of the eukaryotic genome requires precisely coordinated replication of the entire genome each time a cell divides. To achieve this coordination, eukaryotic cells use an ordered series of steps to form several key protein assemblies at origins of replication. Recent studies have identifie...
DNA replication in eukaryotes is a conserved system that only allows for DNA replication to occur once throughout each cell cycle. The replication of chromosomal DNA in eukaryotes is critical for the duplication of a cell and is required for the maintenance of the eukaryotic genome. Steps in ...
The Origin Recognition Complex (ORC) binds to sites in chromosomes to specify the location of origins of DNA replication. The S. cerevisiae ORC binds to specific DNA sequences throughout the cell cycle but becomes active only when it binds to the replica
DNA replication is the process by which DNA is duplicated or copied prior to cell division, and which allows the daughter cell to retain a set of its own genetic material. During this process, the two DNA strands are unwound...
State the role of telomerase in DNA replication Eukaryotic genomes are much more complex and larger in size than prokaryotic genomes. Eukaryotes also have a number of different linear chromosomes. The human genome has 3 billion base pairs per haploid set of chromosomes, and 6 billion base pairs ...
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128–134 (1992). The first article describing the ORC. Article CAS PubMed Google Scholar Remus, D., Beall, E. L. & Botchan, M. R. DNA topology, not DNA sequence, is a critical ...
Eukaryotic DNA replication refers to the process by which eukaryotic cells duplicate their DNA, involving the binding of the origin recognition complex (ORC) to replication origins, the formation of pre-replicative complexes (pre-RCs), and the initiation of DNA replication by helicase activity. This...
in14N. Meselson and Stahl noted that after one generation of growth in14N, the single band observed was intermediate in position in between DNA of cells grown exclusively in15N or14N. This suggested either a semiconservative or dispersive mode of replication. Some cells were allowed to grow ...
Replication origins in eukaryotic cells never fire more than once in a given S phase. Here, we summarize the role of cyclin–dependent kinases in limiting DNA replication origin usage to once per cell cycle in the budding yeast Saccharomyces cerevisiae. We have examined the role of different cyc...