Second, the increased fork speed may result from dysregulation of genes involved in DNA replication. Consistent with the last explanation is the fact that only two ICF cell lines out of three had a significant change in DNA replication kinetics. A similar variability was found in gene expression...
During DNA replication, chromatin organization is disrupted ahead of the replisome and restored behind, on the two daughter strands1–3. To maintain nucleosomal density, parental histone recycling must be complemented by deposition of newly synthesized histones. Duplication of chromatin thus necessitates ...
How can a DNA polymerase use a protein as a primer for replication? Describe DNA replication. In replication, in which direction would the lagging strand of the new DNA strand be going? Describe the Semiconservative model for DNA replication. What is the difference between plasmid replicatio...
complete DNA replication with a ploidy consistent with 16 genome equivalents per cell [37]. However, in the same cells the authors also find that some DNA is represented by only 4 genome equivalents, which is consistent with the presence of heterochromatic sequences that are not replicated to ...
A plausible explanation for this has been proposed previously: if unequal crossover events between rDNAs of two chromosomes occurred in the proximal region to centromeres, this may result in the exchange of not only a fraction of the rDNA but also the centromeres themselves. Such an event is ...
An epigenetic mark prevalent across different kingdoms of life, DNA methylation is involved in regulation of gene expression and DNA replication and can alter chromatin's three-dimensional structure and physico-chemical properties [2]. Additionally, DNA methylation plays important roles in embryonic ...
[6]. It has been extensively detected in viruses, bacteria, protists, fungi, algae, etc. As the other important epigenetic modification, 4mC protects host DNA from the degradation of restriction enzymes and corrects prokaryotic DNA replication errors, and controls the DNA replication and cell ...
(2) the P22 genome is replicated by rolling circle replication, which produces long concatemers of P22 DNA. A specific sequence on the phage DNA (pacsite) initiates the packaging of these concatemers into phage heads using a headful mechanism [31]; (3) the packaging of phage DNA continues...
Some function in the replication of the genome, but most participate in specialized DNA repair and DNA damage tolerance processes. The activity of these DNA polymerases will affect the response of a cell to DNA-damaging carcinogens and chemotherapeutic agents. Some DNA polymerases catalyse DNA ...
This enabled us to evaluate real-world outcomes and predictors of response to anti-PD-1 therapy in children with cancers driven by germline DNA replication repair deficiency. Uniquely, this also provided us the opportunity to investigate the efficacy of ICI in individuals with synchronous malignancies...