However, the specific function of the RecN protein in DSB repair is poorly understood. This is in great part due to the limited biochemical information available to help explain the role of RecN in this process. In this work, we use the pure RecN protein from to describe the biochemical ...
;在DSBR过程中,RecN可结合于经RecBCD处理的断裂dsDNA的双链或单链(3'链)区,已形成的RecA蛋白丝则可(通过阻止RecN从3'链滑落)促进RecN在3'链上的聚集,而聚集于3'链的RecN又可俘获另一供体双链(需要RecN与ATP的结合,但无需RecN对ATP的水解,虽然RecN具有ssDNA依赖性ATP酶活性。),并可通过栓系3'链和供体...
A unique DNA repair and recombination gene (recN) sequence for identification and intraspecific molecular typing of bacterial wilt pathogen Ralstonia solanacearum and its comparative analysis with ribosomal DNA sequences. Journal of Biosciences 38, 267-78....
在正常细胞中,内,外源因素 都可以造成 DNA 损伤,这种损伤可以迅速被损伤 诱导反应 (DNA damage response,DDR) 识别, 启动 DNA 修复程序."SOS"是国际上紧急呼救的 通用信号,1974 年 Radman 等[1] 提出了细菌 DNA 修复系统的"SOS repair",故通常把细菌 DNA 损 伤修复称为 SOS 反应.SOS 反应是细菌适应环境,...
When known DNA-repair proteins are excluded, the STRING network is still significant compared with random sets of the same number of E. coli proteins (p = 8 × 10−6, hypergeometric test), indicating that the associations are not solely via DNA-repair-protein associations. When both DNA-...
Genetic recombination in Bacillus subtilis 168: effect of recN, recF, recH and addAB mutations on DNA repair and recombination. A recN ( recN1 ) strain of Bacillus subtilis was constructed. The effects of this and recF, recH and addAB mutations on recombination proficiency wer... J.C. Al...
To date, at least 12 FA genes have been found deleted or mutated in FA cells, and 10 FA gene products form a core complex involved in FA/BRCA2 DNA repair pathway?FA pathway. 目前已经发现至少12种FA基因的缺失或突变能够引起FA表型的出现,其中10种相应的编码蛋白形成FA复合物共同参与FA/BRCA2 ...
2) DNA damage-repair/toleration protein DNA损伤修复蛋白 例句>> 3) Repair proteins of DNA DNA修复蛋白类4) DNA repair related genes DNA修复相关基因 1. Objective To compare gene expression gene profilie of nasopharyngeal c arcinoma(NPC) tissue with that of normal nasopharyngeal tissues by ...
RecN protein is produced in high amounts during the first part of the SOS response. It is possible that the RecN-mediated 'compact DNA' stage at the beginning of the SOS response serves to stabilize damaged DNA prior to recombination and repair. 展开 ...
The SsbA protein becomes phosphorylated (19). The biochemical activities associated with SsbA in DNA repair are poorly understood, as well as the role of its phosphorylation. Genetic studies provide evidence that E. coli and B. subtilis cells might use different pathways to load RecA onto SsbA-...