另一类单链修复机制被称为核苷酸切除修复(nucleotide excision repair,NER),这是一种大片段的碱基切除修复机制,主要负责因紫外线辐射引起的DNA结构受损,或因此导致的DNA转录和复制错误(图2C)[32]。已被证实的是,NER是唯一一种能够纠正紫外线诱导的DNA改...
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining genomic stability. However, if deployed in an inappropriate cellular context, these same repair functions can mediate chromosome rearrangements that underlie various human diseases, ranging from developmental disorders ...
NER and MMR pathways recognize distortions and mismatches/bubbles on DNA and cleave DNA as part of “repair” processing. However, these DNA strand breaks could lead to chromosome breakage and other mutagenic events if repair is not completed faithfully. Interestingly, many other repair proteins requ...
[15] Ranjha, L., Howard, S. M. & Cejka, P. Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes [J]. Chromosoma 127, 187–214 (2018). [16] Lodovichi, S.et al. Effect of BRCA1 missense variants on gene reversion in DNA d...
与DNA损伤不同,DNA突变一旦在两条DNA链上都出现碱基变化,酶就无法识别和修复,从而导致蛋白质功能和调节发生改变。 核苷酸切除修复(NER)是用途最广的DNA修复途径,可修复多种物理和化学因素导致的DN…
【摘要】 DNA双链断裂(DSB)作为最为严重的一种DNA损伤类型,如不能及时、妥善的修复将极大的影响细胞基因组的稳定性,甚至导致细胞死亡。在 E.coli中,DSB可由外源性因素(如电离辐射、拟放射药物、拓扑异构酶…
To investigate whether defects in other DNA repair pathways also promote DA survival, we knocked down, pan-neuronally, several components of the nucleotide excision repair (NER) and non-homologous end joining (NHEJ) pathways in BY273 and nth-1;BY273 animals. In contrast to the neuroprotective ...
XPA and MSH2 genes are able to differentiate normally as the wild-type cells (Figures S2I–S2M), suggesting that attenuated differentiation is specifically attributed to the loss of the FA pathway, rather than a general mutational stress from unrepaired nucleotide excision repair lesions or ...
Cells are constantly under DNA damage stress posed by endogenous or environmental agents.1,2A complex DNA damage response (DDR) network has been evolved to maintain the integrity and fidelity of genomic DNA. These DDR networks include DNA repair pathways themselves and a repertoire of regulatory sig...
alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the...