To maintain genome integrity and ensure cell survival, bacteria have evolved several DNA repair pathways to correct different types of DNA damage and non-canonical bases, including strand breaks, nucleotide modifications, cross-links, mismatches and ribonucleotide incorporations. Recent advances in genome...
DNA repair: pathways in balance
repair pathways are highly conserved among eukaryotes and often show a remarkable similarity to bacterial repair systems as well. Consistently, central components of the mismatch repair pathway (
PARP1, functioning as a DNA damage sensor, can be activated by DNA lesions, forming PAR chains that serve as a docking platform for DNA repair factors with high biochemical complexity. Here, we highlight molecular insights into PARylation recognition, the expanding role of PARylation in DDR ...
BCCIP promotes resistance of gastric cancer to cisplatin by modulating DNA damage repair pathways JIA Zhe1ZENG Guangyan1ZOU Peng1FU Zongli1ZHOU Chuzhou2RAO Xionghui1ZHOU Yuhang4JIANG Chao3JIN Xinghan1 WENG Nuoqing1 LUO...
3. Mitochondrial DNA repair mechanisms: the BER pathway 4. Mitochondrial DNA repair mechanisms: further pathways 5. Specific aspects and further factors of organelle DNA repair mechanisms 6. Sub-organellar localization of DNA repair 7. Mitochondrial DNA damage, genetic processes and disease 8. Mitocho...
【摘要】 DNA双链断裂(DSB)作为最为严重的一种DNA损伤类型,如不能及时、妥善的修复将极大的影响细胞基因组的稳定性,甚至导致细胞死亡。在 E.coli中,DSB可由外源性因素(如电离辐射、拟放射药物、拓扑异构酶…
1 Up-regulated genes and pathways during memory formation. a Expanded reactome analysis (String database, STRING-db.org) outlining individual functional clusters of up-regulated genes enriched in inflammation, cytokine release, and cell cycle/DNA repair pathways. b Gene ontology analysis showing ...
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the se
alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the...