How are mutations caused in DNA replication? What is the function of DNA ligase in recombinant technology? What is the structure of proteins and what will happen to protein's function if its shape changes? How are DNA replication and protein synthesis different? How d...
(Most Recent Common Ancestor), Mutation Rates, Mutations, Named Variant, Non-Matching Variant, Notable Connections, Novel Variants, Paternal Inheritance, Phased Matches, Phasing, Phylotree, Pileup Regions, Population Genetics, Private Variant, Projects, Public Mitochondrial DNA Tree, Recombination, ...
The γ protein and the τ protein are both products of the same dnaX gene. This is a case where frameshifting termination of protein synthesis plays a role in producing different proteins from the same gene. Mutants constructed with a frameshift in the dnaX gene that abolish production of...
For elephants,at least,part of the answer may be the gene commonly known as p53,which also helps humans and many other animals repair DNA damaged during replication(复制) Elephants have an amazing 20 copies of this gene.Those copies,each with two variations produce a total of ...
The answer to these questions may well be that you’re still working on “proof,” but you’ll at least want to have documented everything available to date. For me, doing these exercises helps me think about what’s still missing and looking for additional sources if I actually don’t ...
Bacteria carrying a library are grown on agar, transferred to a membrane, and lysed. Released proteins are bound to the membrane. This figure shows only one attached protein, but in reality, a large number of different proteins will be present. These proteins include both those from the librar...
In this study, we report previously unknown nuclear functions of the actin-binding factor profilin-1 (PFN1) in DNA replication, which occur in a context-dependent fashion and require its binding to poly-L-proline (PLP)-containing proteins instead of actin. In unperturbed cells, PFN1 increases...
The enrichment of genes encoding proteins involved in DNA damage response and various RNA-related functions among the genes containing SSB hotpots in the immediate vicinity of TSSs brings a tantalizing possibility that SSBs at TSSs might serve as some sort of sensors of general DNA damage in the...
“belonging to the Motomkin” village, according to theAccomack County, Virginia court records. These men tested as members of haplogroup O-F3288 initially, after taking the Big Y-500 test. However, upgrading to the Big Y-700 produced more granular results and branches reflecting mutations ...
W40 and Y51 mutations are known to impair LEF1 HMG DNA binding [37]; however, whether the Y12 mutation impacts on the DNA binding ability of the HMG domain of TCF/LEF family members is unknown. To answer this question, we mutated Y337 to: i) glutamic acid (e) to introduce a negati...