The unique structure-directing properties of DNA origami nanostructures (DONs) show great potential to specifically manipulate intracellular processes. We report an innovative concept to selectively activate the transcription of a single gene in the developing zebrafish embryo. We reason that engineering a...
DNA origami principles can be invoked for nano-structure generation to form long DNA nanowires as interconnects and short DNA sequences as memory cells. A large number of these elements can be built through methods like PCR amplification. These components can then be self-assembled to create a ...
According to team member Carlos Castro, “nature has produced incredibly complex molecular machines at the nanoscale, and a major goal of bio-nanotechnology is to reproduce their function synthetically. DNA origami enables the precise fabrication of nanoscale geometries.” At issue is the reprogramming ...
Keywords: DNA origami; DNA PAINT; DNA; super-resolution microscopy; SMLM; fluorescence microscopy 1. Introduction The discovery of fluorescent proteins, initially green fluorescent protein (GFP) from jellyfish [1], allowed the use of microscopy to genetically tag and visualize individual proteins. ...
DNA origami delivery system for cancer therapy with tunable release properties. ACS Nano 2012, 6, 8684–8691. [CrossRef] [PubMed] 10. Lee, H.; Lytton-Jean, A.K.R.; Chen, Y.; Love, K.T.; Park, A.I.; Karagiannis, E.D.; Sehgal, A.; Querbes, W.; Zurenko, C.S.; ...
DNA origami as a DNA repair nanosensor at the single-molecule level. Angew. Chem. Int. Ed. 2013, 52, 7747–7750. [CrossRef] [PubMed] 53. Tintore, M.; Aviño, A.; Ruiz, F.M.; Eritja, R.; Fabrega, C. Development of a novel fluorescence assay based on the use of the ...
Structures of nanomechanical DNA origami devices used to visually detect PNA invasion. Figure 7(a. )SStcrhuecmtautriceislluosftrnaatinonoomf ethcehsaynstiecma;laDndN(Ab) sotrruigctaumresi odfetvheicperse-uclsoesidngtozipvpiesruealellmyedntestaencdt PPNNAA. invasion. (a) Schematic illustration...