Each strand has a sugar phosphate backbone linked from the 5′ and 3′ carbon atoms of deoxyribose. At the end of a strand is either a 5′ phosphate group (5′ end) or a 3′ phosphate group (3′ end). One strand of DNA (sense-strand) contains the genetic information in a 5′ ...
DNA is made up of millions ofnucleotides.These are molecules composed of a deoxyribose sugar, with a phosphate and a base (or nucleobase) attached to it. These nucleotides are attached to each other in strands viaphosphodiester bondsto form a ‘sugar-phosphate backbone’. The bond formed is b...
The RNA primers are removed by another DNA polymerase, pol I, and the breaks in the sugar-phosphate backbone are sealed by DNA ligase. (b) A more realistic three-dimensional illustration.[Reproduced with permission from B. Alberts, DNA replication and recombination, Nature 421 (2003) 431–...
Liu T , and Barton JK (2005) DNA Electrochemistry through the Base Pairs Not the Sugar- Phosphate Backbone. J. Am. Chem. Soc 127, 10160-10161.16028914Tao Liu and Jacqueline K. Barton. DNA electrochemistry through the base pairs not the SugarPhosphate backbone. J. Am. Chem. Soc., 127(29...
Pechenaya, V. I. 1993. Influence of electrostatic interactions on the sugar-phosphate backbone conformation in DNA. Biopolymers. 33 :37–44. [ PubMed ]Pechenaya, V. I. 1993. Influence of electrostatic interactions on the sugar- phosphate backbone conformation in DNA. Biopolymers. 33:37-44....
Hypotheses of the origins of RNA and DNA are generally centred on the prebiotic synthesis of a pristine system (pre-RNA or RNA), which gives rise to its descendent. However, a lack of specificity in the synthesis of genetic polymers would probably result
[15], which showed through Fourier-transform infrared spectroscopy (FT-IR) and ultraviolet (UV)–VIS absorption that MTX intercalates into the double helix of DNA along with its external binding to phosphate–sugar backbone. Finally, docking studies have also shown that MTX (Figure 3f) inter...
Two sugar-phosphate chains are paired through hydrogen bonds between A and T and between G and C, thus forming the twin-stranded double helix of the DNA molecule.(more) 3 of 3 DNA strandsIllustration of DNA strands(more) The chemical DNA was first discovered in 1869, but its role in ...
It is important to point out that although there are many different means for topologically modifying DNA molecules, for data storage applications enzymatic nicking (i.e., creating a single-bond cut in the DNA sugar-phosphate backbone via an enzyme) appears to be the most specific, efficient, ...
A., Sequence-Dependent DNA Structure: The Role of the Sugar-Phosphate Backbone. Journal of Molecular Biology 1998, 280 (3), 407- 420.Packer, M. J., Hunter, C. A. (1998) Sequence-dependent DNA Structure: The Role of the Sugar- phosphate Backbone, J. Mol. Biol. 280 (3): 407-420...