ResearchOpen Access02 Dec 2024Communications Biology Volume: 7, P: 1605 SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers DNA methylation is an epigenetic mark that plays a critical role in many biologic...
DNA methylation in the CR-B and CR-C regions of the PD-1 promoter was negatively correlated with PD-1 expression (Fig. 2) (Youngblood et al., 2011). The CR-B and CR-C regions in non-tolerant T cells, which expressed a low level of PD-1, had significantly enriched 5-hydroxy...
DNA methylation is a fundamental epigenetic mark that governs gene expression and chromatin organization, thus providing a window into cellular identity and developmental processes1. Current datasets typically include only a fraction of methylation sites and are often based either on cell lines that under...
2024年3月,南京农业大学张绍铃院士团队在Genome Biology杂志上发表了题为“Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism”的研究论文,文章利用多组学手段,通过对砀山酥梨果实从果实发育到成熟共11个发育阶段的代谢组、蛋白质组、转录组进行全面分析,通过全生育期数据构建...
3月14日,南京农业大学园艺学院张绍铃院士团队在国际基因组学顶级期刊Genome Biology发表了题为 “Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism”的研究文章,利用多组学相结合的方法,揭示了D...
近日,加州大学洛杉矶分校Steven E. Jacobsen教授领导的研究团队在Nature Plants上发表了题为MBD2 couples DNA methylation to transposable element silencing during male gametogenesis的研究论文,揭示了植物MBD2蛋白在精细胞形成期间维持转座子沉默的机制,及其在保障基因组的完整性中发挥的重要功能。
DNA甲基化(DNA methylation)为DNA化学修饰的一种形式,能够在不改变DNA序列的前提下,改变遗传表现。作为最早发现的基因表观修饰方式之一,DNA甲基化在维持正常细胞功能、染色体结构、X染色体失活、基因印记、胚胎发育过程、衰老以及疾病的发生中起着重要的作用。近些年,结合数据驱动的人工智能算法,利用DNA序列建模实现DNA甲基...
近日,华中农业大学果蔬园艺作物种质创新与利用全国重点实验室、湖北洪山实验室张帆教授课题组研究成果以“DNA methylation remodeled amino acids biosynthesis regulates flower senescence in carnation (Dianthus caryophyllus)”为题在New Phytolog...
中国农大新闻网讯近日，动物科学技术学院俞英教授团队在国际知名学术期刊《Molecular Biology and Evolution》（《分子生物学与进化》）上在线发表研究论文《跨物种DNA甲基化比较为牛、绵羊和山羊复杂性状遗传机制提供新见解》（Cross-species comparative DNA methylation reveals novel insights into complex trait genetics ...
近日,动物科学技术学院俞英教授团队在国际知名学术期刊《Molecular Biology and Evolution》(《分子生物学与进化》)上在线发表研究论文《跨物种DNA甲基化比较为牛、绵羊和山羊复杂性状遗传机制提供新见解》(Cross-species comparative DNA methylation reveals novel insights into complex trait genetics among cattle, sheep...