DNA methylation is a common phenomenon in plants. In plant genomes, its level is comparatively lower than that of animal genomes. It is involved in gene regulation and controls many development pathways. Methylation status of particular DNA sequence controls the potential for transition from ...
ResearchOpen Access10 Jan 2025Communications Biology Volume: 8, P: 38 News and Comment X-specific methylation distorts sex Despite theoretical expectations of balanced 1:1 sex ratios between females and males, many dioecious plant species exhibit sex ratio distortions. A recent study in persimmon ...
They have further confirmed that CTCF, a transcription activator, can bind to the promoter region of SOCS1 and contribute to overexpression of SOCS1 in SLE CD4+ T cells by mediating DNA hydroxymethylation and decreasing DNA methylation level at the locus [26]. Abnormal DNA methylation in other ...
2024年3月,南京农业大学张绍铃院士团队在Genome Biology杂志上发表了题为“Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism”的研究论文,文章利用多组学手段,通过对砀山酥梨果实从果实发育到成熟共11个发育阶段的代谢组、蛋白质组、转录组进行全面分析,通过全生育期数据构建...
DNA methylation is a fundamental epigenetic mark that governs gene expression and chromatin organization, thus providing a window into cellular identity and developmental processes1. Current datasets typically include only a fraction of methylation sites
近日,华中农业大学作物遗传改良全国重点实验室、湖北洪山实验室周道绣课题组在Genome biology上发表了题为“DNA methylation remodeling and the functional implication during male gametogenesis in rice”的研究论文。该研究发现,水稻DNA甲基化在雄配子发生过程中存在动态重编程现象,直接影响雄配子发育相关基因表达和生殖,...
DNA methylation is a key epigenetic mark when occurring in the promoter and enhancer regions regulates the accessibility of the binding protein and gene transcription. DNA methylation is inheritable and can bede novosynthesized, erased and reinstated, making it arguably one of the most dynamic upstream...
DNA甲基化(DNA methylation)为DNA化学修饰的一种形式,能够在不改变DNA序列的前提下,改变遗传表现。作为最早发现的基因表观修饰方式之一,DNA甲基化在维持正常细胞功能、染色体结构、X染色体失活、基因印记、胚胎发育过程、衰老以及疾病的发生中起着重要的作用。近些年,结合数据驱动的人工智能算法,利用DNA序列建模实现DNA甲基...
3月14日,南京农业大学园艺学院张绍铃院士团队在国际基因组学顶级期刊Genome Biology发表了题为 “Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism”的研究文章,利用多组学相结合的方法,揭示了D...
(b) orientation-aware fragmentation end distribution for hyper- and hypo-methylated cfDNA in the nucleosomal context in chr12p11.1 loci; (c,d) HCC patients, (e,f) lung adenocarcinoma patients.g–iGenomewide distribution of cfDNA size and methylation level: (g) control subjects, (h) HCC ...