The central dogma of life can be defined in a fairly simple way: DNA makes RNA, which in turn makes proteins: In transcription, your genetic code is transcribed, or written, into RNA. In translation, this RNA is then translated into proteins. Of course, the processes of transcription and ...
1 Beluga Gorilla Centraldogma •Thecentraldogmaistheflowofgeneticinformationwithinabiologicalsystem.Ithasalsobeendescribedas“DNAmakesRNAandRNAmakesprotein”.Section1REPLICATION Section2REVERSETRANSCRIPITIONSection3DNADAMAGEANDREPAIR Section1REPLICATION 1.1DNAreplicationissemi-conservation,semi-discontinuousand...
Here the authors show a function of RBM42 in regulating splicing and translation of the p53-target gene CDKN1A/p21. This makes RBM42 an RNA-binding protein that links splicing and translation to fine-tune gene expression during DNA damage. ...
一个A makes B里面套了另一个A makes B啊.A makes B makes C = A makes B,B makes C
此外,RNAP基因不同,组蛋白修饰水平及转录起始位点也不同。鉴于这一特性,可通过组蛋白修饰的不同组合区分启动子特征,包括聚合酶、基因类型和活性水平等。 图3. ChIP-DIP揭示了LPS刺激mDCs后染色质景观的动态变化 该研究提出了能够同时揭示多个蛋白质-DNA相互作用的创新新技术——ChIP-DIP,显著提高了研究效率。ChIP...
序列特异性 DNA 和 RNA 结合蛋白(如启动子、基因调节蛋白和转录因子)在正常细胞控制和病情(如癌症和特定遗传疾病)中至关重要。这些调节蛋白是潜在的药物靶点,但由于这些蛋白通常寿命短且稀缺,因此需要采用一种快速、灵敏的纯化方法。 要简单、快速、可靠地纯化序列特...
An enzyme calledprimasestarts the process, this enzyme makes a small piece of RNA call aprimer. Thismarksthe starting point for the construction of the newstrandof DNA. An enzyme calledDNA polymerasebinds to theprimerand will make the newstrandof DNA. ...
Nucleic acid sequence evolution has an important role in the development of DRBP function. Emerging studies of rapidly evolving lncRNAs suggest that RNA binding by proteins that were previously thought of as DNA-specific may be a widespread phenomenon. ...
这项新技术被称为“精确 RNA 介导的转基因插入"(Precise RNA-mediated INsertion of Transgenes,简称 PRINT),它利用一些反转录转座子的能力,在不影响其他基因组功能的情况下,有效地将整个基因插入基因组。PRINT将补充CRISPR-Cas技术的公认...
259Altmetric Metrics Abstract Knowing the sequence specificities of DNA- and RNA-binding proteins is essential for developing models of the regulatory processes in biological systems and for identifying causal disease variants. Here we show that sequence specificities can be ascertained from experimental da...