This function of Dna2 is essential for viability in yeast6. The lethality of dna2 mutants, however, can be rescued by the inactivation of the DNA-replication checkpoint5 or Pif17, a 5′-to-3′ DNA helicase responsible for the formation of long 5′-flaps during lagging-strand synthesis8....
DNA helicase is a special type of biological molecule that plays a very important role in DNA replication as well as in transcription. DNA has a double-stranded helical structure with bases, which are paired by hydrogen bonds, inside of the helix. In order for the genetic code held with in...
原文摘要:HARP Is an ATP-Driven Annealing Helicase 【Abstract】 DNA-dependent adenosine triphosphatases (ATPases) participate in a broad range of biological processes including transcription, DNA repair, and chromatin dynamics. Mutations in the HepA-related protein (HARP) ATPase are responsible for Sch...
DNA helicases in recombination and repair: construction of a DuvrD DhelD DrecQ mutant deficient in recombination and repair - Mendonca, Klepin, et al. - 1995 () Citation Context ...hougli RecQ helicase is responsible for abouts75% of conjugal recombination events occurring insrecBC sbcB sbcC...
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DNA cross-linking can hinder the activities of some vital enzymes such as DNA helicases and polymerases.107,108A review described the formation of DNA cross-links due to exposure to various endogenous, environmental and chemotherapeutic agents.106However, elucidation of how this process is regulated ...
In E. coli, the DnaB protein is responsible for unwinding duplex DNA ahead of the replisome (26, 27, 28), and helicase inhibition is known to cause the arrest of replication forks (8, 9, 29, 30). DnaB Helicase Is Unable to Dissociate RNA-DNA Hybrids To test whether or not DnaB ...
What is DNA helicase? What does it do? DNA Replication: DNA replication is an important process that occurs as the cell is beginning to divide into two. This is because the new daughter cell will need its own DNA, and so the original DNA needs to replicate. Answer and Explanation: Beco...
Which component of DNA is responsible for its double-stranded configuration? DNA Configuration: DNA is the genetic code found in cells. The genetic code carries all the heredity information of the organism. DNA has a specific configuration called the 'double helix' to serve its fu...
transiently)stabilizedinthesingle-strandedstate.Thensynthesisofdaughterstrandscanbeinitiatedatthereplicationfork.·Elongationisundertakenbyanothercomplexofproteins.ThereplisomeexistsonlyasaproteincomplexassociatedwiththeparticularstructurethatDNAtakesatthereplicationfork.Itdoesnotexistasanindependentunit(forexample,analogousto...