Inhibitors of e. coli and shigella enterotoxins; used for drugs and dna vaccinesdoi:US6344201 B1"Black holes" in the genomes of bacterial pathogens represent deletions of "anti-virulence" genes, i.e. genes that are detrimental to a pathogenic lifestyle. Identification of the missing genetic ...
DNA damaging anti- cancer drugs may alter guanine residues to mutagenize and kill pro- liferating cells. O6-methyl-2′-deoxyguanosine ( O6-mdGuo), N7-meth- yl-guanosine ( 7meGuo), and 8-oxo-7,8-dihydro-2′-deoxyguanosine ( 8-oxodGuo) represent such DNA lesions. The ...
This class of drugs mainly works by three distinct mechanisms: The attachment of alkyl groups to DNA bases prevents DNA synthesis and RNA transcription, and it results in the DNA being fragmented by repair enzymes in a process to replace the altered bases. The two arms of mustard drugs can c...
It made therapeutic drugs and vaccines. 它能够制造治疗药物和疫苗。 And laboratory workflows that once took weeks or months could now be carried out in just one to two days. 以前在实验室工作流程中需要耗时数周或数月的工作,如今在1-2天内就能完成。 And that's all without any human intervention...
REVIEWS DNA vaccines: ready for prime time? Michele A. Kutzler* and David B. Weiner‡ Abstract | Since the discovery, over a decade and a half ago, that genetically engineered DNA can be delivered in vaccine form and elicit an immune response, there has been much progress in ...
Technological issues, concern because it mutates rapidly and has a the ability of current manufacturers to pro- stemming from production difficulties, are documented capacity to acquire genes from duce vaccines and drugs in response to a pan- crippling the vaccine industry and leading viruses ...
3. Mechanisms of internalization and processing 4. Enhancing the duration of immune protection using adjuvants 5. Manufacturing and engineering DNA vaccines 6. Safety and stability of DNA vaccines 7. Plasmid delivery 8. Controlling gene expression through plasmid engineering and gene circuits 9. Techni...
the widespread popular misconceptions and opposition togenetically modified foods, drugs and vaccines produced by recombinant DNA methods, and genetic research in general. Now decades later, many of the hotly debated risks initially imagined have not been observed. Several substantial revisions in the ...
The therapies that are currently approved for MS are drugs that seriously modulate the immune system. Steinman said, “Tysabri blocks the ability of the immune system to traffic into the brain. It’s very good in shutting down MS, but if your brain has to fight an infection and your immune...
The invention relates to immunogenic preparations or vaccines comprising, on the one hand, a plasmid encoding and expressing a gene from PCV, in particular selected from the group c