Cloning and functional analysis of anti-double strand DNA IgG autoantibodies using the phage-display method. International Journal Of Molecular Medicine 1999;3(4):-390Suzuki M,Katsube Y,Suzuki H,et al.Cloning and functional analysis of anti-double strand DNA IgG autoantibodies using the phage-...
DNA双链断裂（DNA double strand breaks，DSBs）是DNA损伤最严重的形式，在真核细胞中，DNA DSBs主要通过同源重组（homologous recombination，HR）和非同源末端连接（non-homologous end joining，NHEJ）两种方式进行修复。HR修复发生在细胞周期的S和G2阶段,受损的DNA以姐妹染色单体上的同源序列为模板进行精准修复。NHEJ...
DNA双链断裂(DNA double strand breaks,DSBs)是DNA损伤最严重的形式,在真核细胞中,DNA DSBs主要通过同源重组(homologous recombination,HR)和非同源末端连接(non-homologous end joining,NHEJ)两种方式进行修复。HR修复发生在细胞周期的S和G2阶段,受损的DNA以姐妹染色单体上的同源序列为模板进行精准修复。NHEJ在修复DSBs...
The alternative non-homologous end-joining (NHEJ) pathway promotes DNA double-strand break (DSB) repair in cells deficient for NHEJ or homologous recombination, suggesting that it operates at all stages of the cell cycle. Here, we use an approach in which DNA breaks can be induced in G1 cel...
2. The end-protection problem originates from the structural similarity between telomeres and DNA double-strand breaks, which can lead to recognition of the telomere by the DNA damage surveillance machinery2. When telomeres are falsely recognized as DNA damage, they are processed by the non-...
To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells respond to various forms of genotoxic stress, including DNA double-stranded breaks (DSBs), through the activation of DNA damage response signaling networks. In respo
例如双链dna(double-stranddna,dsdna),主要是通过pcr扩增来进行生物素标记:在pcr的dntps中加入一定比例的标记有生物素的dutp,通过pcr标记有生物素的dutp被加入到新合成的dsdna双链中,得到标记有生物素的dsdna。但是通过pcr扩增来进行生物素标记的方法需要运用pcr,一般pcr的扩增体系的总体积为10μl或者50μl。所以,...
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010] ...
DNA recombination and repair protein; Double strand break repair protein MRE11A; Double-strand break repair protein MRE11A; endo/exonuclease Mre11. HNGS1; meiotic recombination (S. cerevisiae) 11 homolog A; meiotic recombination 11 homolog A (S. cerevisiae); meiotic recombination 11 homolog A; ...
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. Defect...