Double-strandedDNAtemplatecomprising T7RNApolymerasepromoter (sequence of template strand is 5′-TTCTTATCTT CCAAGCTGTT CGAGCTTGCT GGATTTAGCA CCTTGGTCAT GGCTGATCGC CATTACACCG GTTGCTGAAG CTTCGTCGGG CCAGTCCCTCTATAGTGAGT CGTATTACAG-3′,T7 RNA polymerasepromoter in italics), ...
In either case, high concentrations of Ku and Sir proteins at telomeres may serve, in part, as readily available pools of repair proteins in the event of double-strand breaks. View article Targeting Homologous Recombination Repair in Cancer Henning Willers, ... Lee Zou, in DNA Repair in ...
N = 2 independent experiments with similar results, e, f DNA pulldowns with 5x telomeric (TTAGGC) double-strand (ds) repeats and both respective single-strand (ss) baits, and 5x control (AGGTCA) ds or 5x (AGGTCA) ss repeats. Pulldowns were performed with embryo extracts of T...
本试剂盒是通过DNA损伤后形成的磷酸化的H2AX Ser139产物(即γ-H2AX或γH2AX)间接评估DNA的损伤,也被称为DNA双链断裂染色检测试剂盒(DNA Double Strand Break (DSB) Staining Kit)、细胞双链DNA断裂检测试剂盒(Cellular DNA Double Strand Break Assay Kit)、或H2AX磷酸化检测试剂盒(H2AX Phosphorylation Assay Kit...
DNA double-strand breaks (DSBs) occur every cell cycle and must be efficiently repaired. Non-homologous end joining (NHEJ) is the dominant pathway for DSB repair in G1-phase. The first step of NHEJ is to bring the two DSB ends back into proximity (synaps
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010] ...
The unique biology of the oocyte means that accepted paradigms for DNA repair and protection are not of direct relevance to the female gamete. Instead, preservation of the integrity of the maternal genome depends on endogenous protein stores and/or mRNA
Minor cross-reaction (~5-fold less) has been observed for AU-rich double-stranded RNA. High affinity binding shown for hybrids of 8, 10, 15, and 23 base pairs in length Recombinant versions available from our sister company, Absolute Antibody: ...
ethosuximide 1000 mg/day was again prescribed and 1 month later she had arthralgia and fever and the antinuclear antibody concentration was were 80 UI/ml. Ethosuximide was continued and 3 weeks later the antinuclear antibodies were 640 UI/ml and the anti-double-strand DNA antibodies were 33...
metal toxicity; metal carcinogenesis; DNA double-strand breaks; ATM1. Introduction Metals are abundantly used and transformed by a number of industrial activities such as mining, metallurgy, production of fertilizers, paints, batteries, and more recently, high-tech products. Accidental, environmental ...