2024年5月17日,荷兰癌症研究所生物化学部Thijn R Brummelkamp团队和肿瘤基因组学部Reuven Agami团队等研究人员在Science上发表题目为“DNA damage induces p53-independent apoptosis through ribosome stalling”的研究论文。该研究揭示一种与基因Schlafen 11(SLFN11)和核糖体停滞相关的癌细胞凋亡新机制。研究发现在DNA损伤...
2024年5月16日，来自阿姆斯特丹荷兰癌症研究所生物化学部Thijn R. Brummelkamp团队在Science上发表了题为DNA damage induces p53-independent apoptosis through ribosome stalling的文章。研究发现了p53非依赖的DNA损伤诱导细胞凋亡的信号。作者发现核糖体在稀少亮氨酸编码UUA密码子上停滞，并在全局范围内限制了翻译的启动。
2024年5月17日,荷兰癌症研究所生物化学部Thijn R Brummelkamp团队和肿瘤基因组学部Reuven Agami团队等研究人员在Science上发表题目为“DNA damage induces p53-independent apoptosis through ribosome stalling”的研究论文。该研究揭示一种与基因Schlafen 11(SLFN11)和核糖体停滞相关的癌细胞凋亡新机制。研究发现在DNA损伤...
2024年5月17日,荷兰癌症研究所生物化学部Thijn R Brummelkamp团队和肿瘤基因组学部Reuven Agami团队等研究人员在Science上发表题目为“DNA damage induces p53-independent apoptosis through ribosome stalling”的研究论文。该研究揭示一种与基因Schlafen 11(SLFN11)和核糖体停滞相关的癌细胞凋亡新机制。研究发现在DNA损伤...
(1994) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell, 79, 329-339.Strasser, A., Harris, A.W., Jacks, T., et Cory, S. 1994. DNA dam- age can induce apoptosis in proliferating lymphoid cells via p53-independent...
Hence, it is conceivable FL HSPCs at 14.5 dpc may not have accumulated enough DNA damage to reach threshold p53 activity to induce apoptosis or cell-cycle arrest. The data consistently show that Fancd2−/− FL cells encounter genomic stress that activates DDR elements during replication, not...
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms... DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2 - Strasser, Harris, et al. - 1994 (... Strasser,Andreas,Harris,... - 《Cell》 ...
This shows that there are two separate, but equally effective, apoptotic responses to DNA damage: one is p53 dependent and the other, engaged in the absence of DNA-PK, does not require p53. 展开 关键词: p53-independent apoptosis DNA-PK DNA damage radiation ...
The tumour suppressor p53 is a central player in cellular DNA damage responses. P53 is upregulated and activated by genotoxic stress and induces a transcriptional programme with effectors promoting apoptosis, cell cycle arrest, senescence and DNA repair. For the best part of the last three decades...
As such, we find that heterogeneity in G1 length is p53-dependent but p21-independent, while G1pm arrest is both p21- and p53-dependent. Moreover, that cells lacking p21 have increased levels of DNA damage suggests that p21 is important in maintaining long-term genome stability, consistent ...