DNA结合基序(DNA binding motifs)是指在DNA序列中具有特定功能的DNA结构或序列。DNA结合基序包括可以与DNA相互作用的特定蛋白质结构域,用于调节基因表达、DNA修复、DNA复制等生物学过程。在实际操作中,科学家们经过大量的实验和研究,发现了许多不同的DNA结合基序。 这里我们要讨论的是tead的DNA结合基序。 Tead是一类转...
[3] Choy MK, Movassagh M, Goh HG, Bennett MR, Down TA, Foo RS (September 2010). "Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated". BMC Genomics. 11 (1): 519. doi:10.1186/1471-2164-11-519. PMC 2997012. PMID 20875111. [4] Dahlet T, Argüeso...
Numerous DNA-binding proteins rely on interactions between α-helical portions of the protein with the DNA major groove. A variety of structural motifs have been identified within α-helical DNA-binding proteins, including the helix–turn–helix (HTH), basic-helix–loop–helix (bHLH), basic leuci...
百度试题 结果1 题目有几种DNA-binding motifs?它们怎样与DNA结合?相关知识点: 试题来源: 解析 luxury gene 反馈 收藏
Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 There is evidence that hypoxia-inducible factor-1α (HIF-1α) interacts with the tumor suppressor p53. To characterize the putative interaction, we mapped ... LO Hansson,A Friedler,S Freund - 《Proceedings of the ...
p pBackground/p pDespite extensive efforts to discover transcription factors and their binding sites in the human malaria parasite itPlasmodium falciparum/it, only a few transcription factor binding motifs have been experimentally validated to date. As a consequence, gene regulation in itP. falciparum...
DNA methyltransferases and polycomb repressive complexes, which both lack sequence-specific DNA-binding motifs, are recruited by long non-coding RNA (lncRNA) to specific genomic sites to methylate DNA and chromatin. Increasing evidence indicates that many lncRNAs contain DNA-binding motifs that can ...
Using these data, we attempt to predict DNA-protein contacts by analyzing correlations between binding motifs in DNA and amino acid sequences of TFs. We identify pairs of positions with high correlation between amino acids and nucleotides for FADR, HUTC, and YTRA subfamilies and show that the...
Integrative analysis of tissue- specific methylation and alternative splicing identifies conserved transcription factor binding motifs[J]. Nucleic Acids Res, 2013, 41 :8503-8514. [32]Siegfried Z, Cedar H. DNA methylation :A molecular lock[J]. Current Biology, 1997, 7 :305-307. [33]Weinberg ...
[2] Georgakopoulos-Soares I, Victorino J, Parada G E, et al. High-throughput characterization of the role of non-B DNA motifs on promoter function[J]. Cell genomics, 2022, 2(4).[3] Guiblet W M, Cremona M A, Cechova M, et al. Long-read sequencing technology indicates genome-wide...