^Doherty AJ, Serpell LC, Ponting CP. The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. Nucleic Acids Res. 1996 Jul 1;24(13):2488-97. ^Ling C, et al. Bloom syndrome complex promotes FANCM recruitment to stalled replication forks an...
This hierarchy is represented by defining the lattice separately at the level of DNA base-pairs as lattice units for sequence-specific TF binding and at the level of nucleosomes as lattice units for chromatin state transitions. The general transfer matrix formalism18,39,68,69 considers the ...
The base pairs of a DNA structure are sequenced with the use of a scanning tunneling microscope (STM). The DNA structure is scanned by the STM probe tip, and, as it is being scanned, the DNA structure is separately subjected to a sequence of infrared radiation from four different sources,...
Cation association is more frequent in the minor groove of AT than the GC pairs. In general, the observed water and ion atmosphere around the DNA sequences is the MD simulation is in good agreement with experimental observations. 展开
The B-DNA double-helix has a periodic structure with 10.5 base pairs per turn with a 3.4 Å rise per base pair and a width of approximately 2.0 nm. These highly specific and predictable interactions allow numerous possibilities of designing and constructing sequences which can be used as ...
According to the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), the human genome comprises approximately 3 billion base pairs of DNA [1]. Since the sequence of bases carries the instructions for making proteins and also regulates...
and interstitial regions. These sequences typically form constitutive blocks of heterochromatin that are essential components of structures such as centromeres and telomeres17. The length of satDNA repeating units can vary from a few base pairs to over 1 kilobase pairs, forming arrays that can span...
AT4-mediated gene silencing is orientation-independent and occurs within a distance of 300 base pairs. Furthermore, an increased gene-silencing effect was observed with a tandemly repeated AT4 dimer. The possible mechanism of AT4-mediated gene silencing in bacteria is discussed. 展开 ...
The original method used to determine the sequence ofDNA basepairs that form the genome was invented by Frederick Sanger, from which the nameSanger Sequencingderives. Sanger’s discovery was the breakthrough that allowed thehuman geneticcode to be deciphered; however, the method itself is time-co...
Also, two long DNA sequences with more than a million base pairs are often compared. In these scenarios, the use of exact algorithms such as NW and SW is often prohibitive in terms of execution time. For this reason, faster heuristic methods for local alignment were proposed which do not ...