Learn the difference between DNA and RNA, learn about the 3 types of RNA and their functions and understand the structure and function of mRNA,...
答：其实这个问题比较复杂，水平有限只能简要回答。首先要说的是RNA是能形成双链结构的，比如虽然是单链结构但自身可以形成稳定配对的转运RNA。但RNA不能形成DNA那样长且稳定的双链，所以无法替代DNA形成细胞生物的遗传物质。DNA（脱氧核糖核酸）与RNA（核糖核酸）的化学性质十分相似，区别只在于DNA多了一个”脱氧“，...
DNA- and RNA-binding proteins (DRBPs) constitute a significant fraction of cellular proteins and have important roles in cells. Their functions include control of transcription and translation, DNA repair, splicing, apoptosis and mediating stress responses. ...
DNA and RNA are both types of nucleic acids, which are molecules that contain sets of instructions for cells to make genetic information and proteins. However, there are significant differences between the two of them.This guide will compare and contrast DNA and RNA in terms of structure, func...
RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination. Cell, 2021, 184(5): 1314-1329.e1310 [12] Martin H A, Porter K E, Vallin C, et al. Mfd protects against oxidative stress in Bacillus subtilis independently of its canonical function in ...
RNAP因DNA损伤滞留在DNA模板链上时,会被转录偶联修复因子识别,此时RNAP从模板解离、回溯变位、降解,并引发后续修复蛋白的组装和修复。 例如,细菌中转录偶联因子Mfd,它可以解离模板链上较强损伤处的RNAP同时引发核苷酸切除修过程。有趣的是,它...
and glycosylated molecules even if they play equally important roles in human health. Unlike DNA/RNA or protein detections, where a complementary DNA/RNA strand or an antibody can be used to recognize the targets, obtaining sensors that can recognize...
(DMRs) in colon tumors. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Consistent with the observed phenotype, induction of DACOR1 led to the activation of tumor-suppressor pathways and ...
切除修复交叉互补（ERCC1）基因的过表达与非小细胞肺癌细胞对顺铂的耐药有关29，并对应于增强的DNA修复能力30全球基因组NER （GGR）修复整个基因组的损伤，而一种称为转录偶联修复（TCR）的特定NER通路在活性RNA聚合酶转录期间修复基因。双股断裂的修复 DNA中的双链断裂会导致基因组序列的丢失和重排。这些断裂可以...
总体来说,该研究揭示了RNA和RNA甲基转移酶METTL16通过m6 A非依赖的方式参与DNA损伤修复的机制,这代表了一种DNA末端切割的新型调控方式。在临床转化中, METTL16高表达的PDAC病人有望从PARPi单药或与吉西他滨联合使用中获益,这为PDAC的治疗...