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Nevertheless, its low aqueous solubility and weak inhibition of CYP3A4 are major hurdles for this drug to progress to clinical trials. However, chemical modifications that improve solubility and eliminate CYP3A4 inhibitory activity have facilitated the successful development of AZD6738 (ceralasertib),...
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Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD), but the regulatory mechanisms underlying sex disparity in AD are still not well understood. DNA methylation is an important epigeneti
Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in the context of gene x environment interactions, have
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