目的 研究系统性红斑狼疮(systemic lupus erythematosus,SLE)患者外周血中TCRαβ+CD3+CD4-CD8-T细胞即双阴性调节性T细胞(doublenegative regulatory T cells,DN Tregs)的表达水平及功能,并探讨DN Tregs在SLE疾病进程中的作用.方法 通过流式细胞术检测20例SLE患者及20例健康对照者外周血CD3+TCRαβ+细胞中DN Tregs...
CD4/CD8/CD20/CD66b/CD68/CD163/PD-1/PD-L1/TIM-3/LAG-3/FoxP3/CTLA-4/HLA-DR/STING, and CLDN18.2 were labeled using multiplex immunohistochemistry (m-IHC) to decipher the rate and spatial distribution of T cells, B cells, macrophages, and neutrophils in formalin-fixed, paraffin-embedded ...
Analysis of thymocyte development revealed diminished total thymocyte numbers, accompanied by a significant increase in CD4/CD8 double-negative (DN) thymocytes due to a partial block in the transition from the DN3 to the DN4 stage. This was neither due to increased thymocyte apoptosis nor defects...
CD47则是一个命途多舛的靶点,屡有产品因安全性控制不佳而临床失利[6-8],至今未有药物获批上市。4-1BB(CD137)是一种在CD4+T细胞、CD8+T细胞、NK细胞等免疫细胞表面广泛表达的共刺激受体,也是肿瘤领域的热门靶点。研究表明,4-1BB...
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5.权利要求1‑4任一项所述的嵌合抗原受体,其中,所述跨膜结构域是选自下列蛋白的 跨膜区:T细胞受体的α、β或ζ链、CD3ε、CD3ζ、CD4、CD5、CD8α、CD137、CD152、CD154和PD‑1; 优选地,所述跨膜结构域是选自下列蛋白的跨膜区:CD8α、CD4、PD‑1、CD152和CD154; 优选地,所述跨膜结构域包含序列...
“t细胞”包括表达cd3的所有类型的免疫细胞,包括t辅助细胞(cd4+细胞)、细胞毒性t细胞(cd8+细胞)、自然杀伤t细胞、t调节细胞(treg)和γ-δt细胞。“细胞毒性细胞”包括cd8+t细胞、自然杀伤(nk)细胞和嗜中性粒细胞,这些细胞能够介导细胞毒性反应。商业上可获得的t细胞系的非限制性实施例包括bcl2(aaa)jurkat(crl-2902...