chloride, then charged with a solution of N,N-diisopropylethylamine (36 mL, 200 mmol) in 5 mL of methylene chloride and the reaction solution is warmed to −45°C over a period of 30 min. N,N-Diisopropylethylamine is added over 5 min, then the reaction flask is removed from the C...
The reaction solution was poured into ice-water (300 g), and the product was extracted with isopropyl ether (500 ml)..; The isopropyl ether layer was washed with 10percent aqueous phosphoric acid solution and aqueous sodium chloride solution, successively, and dried (over MgSO4), and the sol...
Overall, the outlined process involving DMSO and acetic acid as co﹕olvent has a computed energy demand on a par with state﹐f‐the art amine‐based processes. However, the insufficient chemical stability of DMSO poses major limitations on processes based on this solvent....
chloride, then charged with a solution of N,N-diisopropylethylamine (36 mL, 200 mmol) in 5 mL of methylene chloride and the reaction solution is warmed to −45°C over a period of 30 min. N,N-Diisopropylethylamine is added over 5 min, then the reaction flask is removed from the C...
Mild reaction conditions, wide functional group tolerance, ease of work-up, and good yields are the noteworthy features of this protocol.doi:10.1016/j.tetlet.2012.08.020Kothanahally S. Sharath KumarToreshettahally R. SwaroopKachigere B. Harsha...
With a 12-residue peptide, CY-12( lo), disulfide formation was observed to be completed in about 1 h when the volume ratios of DMSO were between IO and 30%. The rates increased as the concentration of DMSO increased. At 40-50% DMSO, the reaction was completed within 0.5 h. On the ...
1. Used as a reaction medium for aromatic hydrocarbon extraction, resins and dyes, as well as a solvent for acrylic fiber polymerization and spinning.2. It can be used as an organic solvent, reaction medium, and intermediate in organic synthesis. Extremely versatile...
reaction 41 or that of trimethyl benzyl ammonium ions. 42 As a Nucleophile The DMSO anion behaves as a typical carbanion by reacting with many alkylating agents to prepare more complex sulfoxides. Thus benzyl chloride 43 , or other alkyl chlorides ...
After the completion of reaction, product was filtered under suction, washed with ethanol and dried in dessicator. The microwave synthesis reactor used was Anton Paar Monowave 300. The reactions were carried out in standard 10 ml borosilicate glass vials (G10) that were sealed with a PTFE-...
One of the pharmaceutical industries uses DMSO, as a solvent in the reaction medium and as a reactant for producing Zidovudine, which is an anti-retroviral drug. The unused DMSO present in the aqueous effluent need to be recovered [9]. Conventionally, the recovery operations involve either evap...