骨细胞和牙本质形成细胞研究:Dmp1-Cre-GFP小鼠用于研究骨细胞和牙本质形成细胞的分布、功能及其在骨骼和牙齿发育中的作用。 基因功能研究:通过条件性敲除或激活特定基因,研究这些基因在Dmp1表达细胞中的功能。 骨骼和牙齿发育研究:研究Dmp1表达细胞在骨骼和牙齿发育、矿化和疾病中的作用。
The phenotype of Notch activation in osteocytes was prevented in Dmp1-Cre ; RosaNotch mice hemizygous for the Dmp1-SOST transgene. The effect was associated with downregulated Notch signaling and suppressed Dmp1 and Rosa26 expression. To test whether SOST regulates Notch expression in osteocytes...
相关品系 Dmp1-2A-CreERT2 品系名:C57BL/6Smoc-Dmp1em(2A-CreERT2)1Smoc 品系状态:精子冻存 | 目录号:NM-KI-225004 Dmp1-KO 品系名:C57BL/6Smoc-Dmp1em1Smoc 品系状态:胚胎冻存 | 目录号:NM-KO-200634 Dmp1-Flox 品系名:C57BL/6Smoc-Dmp1em1(flox)Smoc 品系状态:在研 | 目录号:待定...
OPEN Citation: Bone Research (2017) 5, 16049; doi:10.1038/boneres.2016.49 www.nature.com/boneres ARTICLE Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice Joohyun Lim1,5, Joseph Burclaff2, Guangxu He1,3, Jason C...
dentin matrix protein 1 (Dmp1) gene accompanied by the Cre gene.Results We confirmed that Dmp1-T2A-Cre mice showed high Cre expression in osteoblasts, osteocytes, odontoblasts, and periodontal ligament cells and that the 2A self-cleaving peptide efficiently produced both Dmp1 and Cre proteins....
The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent ...
In order to determine if activated PI3K signaling in bone cells causes overgrowth, we used Tg(BGLAP-Cre) and Tg(DMP1-Cre) mouse strains to somatically activate a disease-causing conditional Pik3ca allele (Pik3caH1047R) in osteoblasts and osteocytes. We observed Tg(BGLAP-Cre);Pik3caH1047R/+ ...
Histology of Dmp1-GFP and Dmp1Cre/Ai9 bones.Elena, TorreggianiBrya, G. MatthewsSlavica, PejdaIgor, MaticMark, C. HorowitzDanka, GrcevicIvo, Kalajzic
PP; AG1; Dmp; DMP-1; AV020965 染色体位置 5 NCBI ID 13406 MGI ID 94910 Ensembl ID ENSMUSG00000029307 Pubmed Dmp1 人类同源基因 DMP1 品系描述 将2A-Cre插入到小鼠Dmp1基因终止密码子处。 *使用本品系发表的文献需注明: Dmp1-2A-Cre mice (Cat. NO. NM-KI-225066) were purchased from Shanghai...
Q. (2007). DMP1-targeted Cre expression in odontoblasts and osteocytes. J. Dent. Res. 86, 320-325.Lu Y, Xie Y, Zhang S, Dusevich V, Bonewald LF, Feng JQ. 2007. DMP1- targeted Cre expression in odontoblasts and osteocytes. J Dent Res. 86(4):320-325....