DLST是α-酮戊二酸脱氢酶复合体(KGDHC)的核心组成酶,位于三羧酸循环(TCA循环)的关键步骤中。 代谢功能:催化α-酮戊二酸转化为琥珀酰辅酶A,这是TCA循环中第二次氧化脱羧反应,直接影响细胞能量(ATP)的生成。 结构特征:其基因位于人类染色体14q24.3,编码的酶蛋白通过硫辛酰基结构域与其他组分协同...
Here we show that high expression of dihydrolipoamide S-succinyltransferase (DLST), a tricarboxylic acid (TCA) cycle enzyme, predicts poor overall and recurrence-free survival among TNBC patients. DLST depletion suppresses growth and induces death in subsets of human TNBC cell lines, which are ...
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RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook AcronymDefinition DLSTDouble Locus Sequence Typing(epidemiological surveillance) DLSTDépartement Licence Sciences et Technologies(French: Licensing Department of Science and Technology; Joseph Fourier University; France) ...
We report the identification of a novel succinated protein, dihydrolipoyllysine-residue succinyltransferase (DLST), a component of the 伪-ketoglutarate dehydrogenase complex (KGDHC) of the tricarboxylic acid (TCA) cycle. Succination of DLST reduced KGDHC activity in the brainstem (BS) and olfactory...