A key player in the mitochondrial fission process is dynamin related protein 1 or DRP1, a GTPase that oligomerizes around the outer mitochondrial membrane to cause mitochondrial fission17. DRP1 also regulates apoptosis15,18,19,20. Under conditions that drive apoptosis, DRP1 promotes a type of ...
UMAP of key subcluster transcripts enriched within microglial/macrophage population; pan microglial/macrophage marker (Csf1r), homeostatic microglia (Siglech), BAMs (Cd163), DIMs (Ms4a7), DIM2 (Igf1) and DIM3 (Atp8b4). f Dot plot showing expression of sub-cluster specific markers. g ...
The dilate option in Volocity software was then used to make a second region of interest expanded 20 μm from the first in all directions. The donut-shaped area in the middle was used for intensity measurements. The sum intensity was divided by the donut area to calculate the mean density ...