新的一期!感受经典!在老派嘻哈的律动节拍中出发!一起享受本期嘉宾 CYS 带来的四十分钟黑胶 Mix 🎵(Hip Hop, Funk / Soul, Jazz, etc), 视频播放量 8377、弹幕量 5、点赞数 262、投硬币枚数 137、收藏人数 296、转发人数 54, 视频作者 REANALOG, 作者简介 Good Vibe, Si
Vinyl Set | DJ CYS @ Motel 106(25.1.25) 21 1-26 30:17Vinyl Set | DJ CYS @ Black Moon(25.1.18) 47 1-26 01:05:09Vinyl Set | DJ CYS @ Black Moon(24.12.24) 49 1-1 01:09:28Vinyl Set | DJ CYS @ Motel106(24.12.13) 27 2024-12-14 ...
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Interestingly, expression of mutant DJ-1 did not affect cell death following simulated IRI (Figure 1a: cell death: L166P 55.1±3.2%, Cys106A 62.8±7.3% versus vector control 52.9±4.7%; n ¼ 5, NSP40.05). Cell death in un-transfected time-matched normoxic control cells was o5.0%, ...
DJ-1 with Cys106-SOwas detected in these cells by mass spectrometry analysis. Moreover, ubiquitination of Cys106-SODJ-1 was identified, which suggests that this oxidized isoform is targeted for proteasomal destruction. Furthermore, we performed controlled oxidation using HOin A549 cells with DJ-1...
(reviewed in Refs.275,454). What is clear is that DJ-1 is cytoprotective in a number of different contexts; this activity requires a conserved cysteine (Cys106 in mammals).Oxidationof this cysteine to cysteine sulfinic and cysteinesulfonic acidsoccurs underoxidative stressconditions, andoxidationof...
The critical role of Cys-106 in the biological function of DJ-1 has been demonstrated, and recent studies indicate that DJ-1 acts as a sensor of oxidative stress by regulating the gene expression of antioxidative defense. Specific antibodies against Cys-106-oxidized DJ-1 have been developed, ...
These results suggest that Cys-106 is the most sensitive among three cysteine residues to oxidative stress, and that DJ-1 function is regulated, in terms of the intracellular redox state, by oxidation of Cys-106. 展开 关键词: DJ-1 Proteome Oxidative stress Cysteine sulphonic acid Two-...