Memorandum of Understanding Between the Division of Select Agents and Toxins Center for Disease Control and Prevention and the Food and Drug AdministrationJeffrey Shuren
ability to 1) quickly elucidate alterations in protein expression levels, 2) detect post-translational modification and mRNA processing events, and 3) dissect molecular networks associated with drug administration or exposure to environmental factors (for example, toxins, infectious agents, or radiation)...
Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N-methylglucamide, decanoyl-N-methylglucamide, Triton® X-100, Triton® X-114, Thesit®, Isotridecypoly(ethylene glycol ether)n, 3-[(3-cholamido...
Since Leishmania and Trypanosoma are trypanosomatids, repurposing NANPDB3614 for the development of therapeutic agents for leishmaniasis can be explored. 3.10. Ligand Efficiency-Based Metrics for Selected Compounds Quality metrics for the top compounds such as the inhibitory constant (Ki), ligand ...
ability to 1) quickly elucidate alterations in protein expression levels, 2) detect post-translational modification and mRNA processing events, and 3) dissect molecular networks associated with drug administration or exposure to environmental factors (for example, toxins, infectious agents, or radiation)...