Breast cancer (BC) cell lines are useful experimental models to understand cancer biology. Yet, their relevance to modelling cancer remains unclear. To better understand the tumour-modelling efficacy of cell lines, we performed RNA-seq analyses on a comb
There are other E3 enzymes in vertebrates that have no obvious homologues in yeast. Vertebrate-specific E3s include Pc2, a polycomb group protein [31], and RanBP2, a large nuclear pore protein that localizes to the cytoplasmic face of the nuclear pore complex (NPC) [32]. No mitotic role ...
After the chromosome seperates, the cell seals off, Final Phase of Mitosis. Cytokinesis division of the cytoplasm to form two separate daughter cells Cytoplasm the portion of the cell outside the nucleus Mitotic spindle a structure made of microtubules that controls chromosome movement during mitosis...
The centromere is a specialized chromosomal region that directs the formation of the kinetochore, a huge protein assembly that acts as the attachment site for spindle microtubules and carries out chromosome movement during cell division. Centromere loss or the presence of extra centromeres adversely af...
Mobil factoryMost of the properties we associate with life are properties of the cytoplasm .Much of the mass of a cell consist of this semifluid substance ,with is bounded on the outside by the plasma membrane .Organelles are suspended within it ,supported by the filamento...
As such the kinetochore seems to function as a catalytic platform upon which a 'wait anaphase' signal is created. Such a catalytic model could be an explanation of how only one single unattached kinetochore can inhibit the APC/C within the entire cell to such an extent that it can delay ...