Breast cancer (BC) cell lines are useful experimental models to understand cancer biology. Yet, their relevance to modelling cancer remains unclear. To better understand the tumour-modelling efficacy of cell lines, we performed RNA-seq analyses on a comb
During division, certain cellular contents can be distributed unequally; daughter cells with different fates have different needs. Septins are proteins that participate in the establishment and maintenance of asymmetry during cell morphogenesis, thereby
There are other E3 enzymes in vertebrates that have no obvious homologues in yeast. Vertebrate-specific E3s include Pc2, a polycomb group protein [31], and RanBP2, a large nuclear pore protein that localizes to the cytoplasmic face of the nuclear pore complex (NPC) [32]. No mitotic role ...
The centromere is a specialized chromosomal region that directs the formation of the kinetochore, a huge protein assembly that acts as the attachment site for spindle microtubules and carries out chromosome movement during cell division. Centromere loss or the presence of extra centromeres adversely af...